Glutamate ionotropic receptor AMPA type subunit 2 (Q28563000)

ionotropic glutamate receptor, metazoa

1 reference

Receptor, ligand binding region, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ionotropic glutamate receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

14 February 2019

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

ionotropic glutamate receptor activity

4 references

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

AMPA glutamate receptor activity

4 references

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

calcium channel regulator activity

1 reference

14 February 2019

NSF binding to GluR2 regulates synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

30 references

14 February 2019

Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

rDLG6: a novel homolog of Drosophila DLG expressed in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

AMPA receptor subunit-specific regulation by a distinct family of type II TARPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

NSF binding to GluR2 regulates synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Involvement of myosin Vb in glutamate receptor trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

NSF binding to GluR2 regulates synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

cytoskeletal protein binding

1 reference

14 February 2019

Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

kainate selective glutamate receptor activity

1 reference

14 February 2019

Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

3 references

14 February 2019

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

NSF binding to GluR2 regulates synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

rDLG6: a novel homolog of Drosophila DLG expressed in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

identical protein binding

4 references

14 February 2019

Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Crystal structure and association behaviour of the GluR2 amino-terminal domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

EXP

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

immunoglobulin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

cell component

endoplasmic reticulum

1 reference

14 February 2019

endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

integral component of plasma membrane

1 reference

14 February 2019

Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

ionotropic glutamate receptor complex

1 reference

14 February 2019

The structure and function of glutamate receptor ion channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

2 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

synaptic vesicle membrane

1 reference

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

AMPA glutamate receptor complex

3 references

14 February 2019

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

4 references

14 February 2019

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

3 references

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

3 references

14 February 2019

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

1 reference

14 February 2019

Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

postsynaptic membrane

1 reference

14 February 2019

Schaffer collateral - CA1 synapse

3 references

14 February 2019

Presynaptic PICK1 facilitates trafficking of AMPA-receptors between active zone and synaptic vesicle pool

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals.

EXP

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

integral component of postsynaptic membrane

1 reference

14 February 2019

Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

integral component of presynaptic membrane

integral component of postsynaptic density membrane

1 reference

14 February 2019

Presynaptic PICK1 facilitates trafficking of AMPA-receptors between active zone and synaptic vesicle pool

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

regulation of receptor recycling

biological process

1 reference

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

2 references

chemical synaptic transmission

1 reference

14 February 2019

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression

response to lithium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

IEP

receptor internalization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

ion transmembrane transport

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

ionotropic glutamate receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

establishment of protein localization

ISS

1 reference

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

positive regulation of synaptic transmission

IMP

1 reference

14 February 2019

Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

IMP

protein tetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

NSF binding to GluR2 regulates synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

regulation of postsynaptic membrane potential

IMP

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate

response to fungicide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19491

Receptor, ligand binding region

IEP

has part(s)

1 reference

Ionotropic glutamate receptor domain

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

1 reference