Gap junction protein, alpha 1 (Q28562630)

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mammalian protein found in Rattus norvegicus
  • Gja1
  • gap junction 43 kDa heart protein
  • gap junction alpha-1 protein
  • gap junction membrane channel protein alpha 1
  • connexin 43
  • connexin k1
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Language Label Description Also known as
English
Gap junction protein, alpha 1
mammalian protein found in Rattus norvegicus
  • Gja1
  • gap junction 43 kDa heart protein
  • gap junction alpha-1 protein
  • gap junction membrane channel protein alpha 1
  • connexin 43
  • connexin k1

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover.
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1.
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Eps15 interacts with ubiquitinated Cx43 and mediates its internalization
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
retrieved
8 April 2019
stated in
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IPI
cell component
plasma membrane
determination method
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
TAS
retrieved
8 April 2019
stated in
Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IEA
retrieved
8 April 2019
stated in
N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Redistribution of connexin43 in regional acute ischemic myocardium: influence of ischemic preconditioning
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
gap junction
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IEA
retrieved
8 April 2019
stated in
Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Redistribution of connexin43 in regional acute ischemic myocardium: influence of ischemic preconditioning
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
connexin complex
determination method
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Characterization of the Structure and Intermolecular Interactions between the Connexin40 and Connexin43 Carboxyl-terminal and Cytoplasmic Loop Domains
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IEA
retrieved
8 April 2019
stated in
Membrane topology and quaternary structure of cardiac gap junction ion channels
GOA
curator
UniProt
UniProt protein ID
P08050
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Individual gap junction plaques contain multiple connexins in arterial endothelium
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
retrieved
8 April 2019
stated in
Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08050
determination method
IDA
biological process

Identifiers

 
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