Calcium/calmodulin dependent serine protein kinase (Q28561763)

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mammalian protein found in Rattus norvegicus

peripheral plasma membrane protein CASK
peripheral plasma membrane protein CASK-like
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Cask

Language	Label	Description	Also known as
English	Calcium/calmodulin dependent serine protein kinase	mammalian protein found in Rattus norvegicus	peripheral plasma membrane protein CASK peripheral plasma membrane protein CASK-like calcium/calmodulin-dependent serine protein kinase (MAGUK family) Cask

Statements

1 reference

17 November 2021

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

L27 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

L27 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate kinase-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CASK, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate kinase/L-type calcium channel beta subunit, protein family

1 reference

based on heuristic

inferred from protein domain or family

L27 domain, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein kinase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein serine/threonine kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein binding

determination method

7 references

14 February 2019

CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Transcriptional modification by a CASK-interacting nucleosome assembly protein

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

calmodulin binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

2 references

protein C-terminus binding

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

PDZ domain binding

determination method

4 references

14 February 2019

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

CASK associates with glutamate receptor interacting protein and signaling molecules

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

neurexin family protein binding

determination method

1 reference

14 February 2019

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

postsynaptic density

determination method

1 reference

14 February 2019

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

basolateral plasma membrane

determination method

1 reference

14 February 2019

mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

1 reference

14 February 2019

CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein-containing complex

determination method

neuronal cell body

determination method

1 reference

14 February 2019

Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

1 reference

14 February 2019

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

ciliary membrane

determination method

1 reference

14 February 2019

Scaffolding proteins in highly purified rat olfactory cilia membranes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

synaptic membrane

determination method

3 references

14 February 2019

Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

14 February 2019

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

apical dendrite

determination method

1 reference

14 February 2019

Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

determination method

1 reference

14 February 2019

Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

biological process

regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

CASK point mutation regulates protein-protein interactions and NR2b promoter activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

cerebral cortex development

determination method

1 reference

14 February 2019

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

positive regulation of insulin secretion

determination method

1 reference

14 February 2019

Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

positive regulation of dendritic spine morphogenesis

determination method

1 reference

14 February 2019

SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

protein localization to plasma membrane

determination method

1 reference

14 February 2019

A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62915

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

Guanylate kinase-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

Guanylate kinase/L-type calcium channel beta subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

Guanylate kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

L27 domain, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

CASK, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62915

Identifiers

RefSeq protein ID

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000069498

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000069498

ENSRNOP00000072295

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000072295

ENSRNOP00000074587

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000074587

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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