Opioid receptor, mu 1 (Q28561662)

http://www.ebi.ac.uk/interpro/protein/P33535

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

G-protein alpha-subunit binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

G protein-coupled receptor activity

5 references

14 February 2019

The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

beta-endorphin receptor activity

voltage-gated calcium channel activity

1 reference

14 February 2019

Activation of μ opioid receptors inhibits transient high- and low-threshold Ca 2+ currents, but spares a sustained current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

6 references

14 February 2019

Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

protein C-terminus binding

IPI

1 reference

14 February 2019

Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

protein domain specific binding

IPI

1 reference

14 February 2019

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Retracted: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling and CREB Activation of Acute Morphine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

G-protein beta-subunit binding

morphine receptor activity

IPI

4 references

14 February 2019

The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Side chain modifications change the binding and agonist properties of endomorphin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Retracted: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling and CREB Activation of Acute Morphine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

integral component of plasma membrane

1 reference

14 February 2019

Integrins regulate opioid receptor signaling in trigeminal ganglion neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Integrins regulate opioid receptor signaling in trigeminal ganglion neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

integral component of membrane

2 references

2 references

1 reference

14 February 2019

Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Integrins regulate opioid receptor signaling in trigeminal ganglion neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

integral component of postsynaptic membrane

1 reference

14 February 2019

Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

integral component of presynaptic membrane

1 reference

14 February 2019

Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

acute inflammatory response to antigenic stimulus

biological process

1 reference

14 February 2019

Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

G protein-coupled receptor signaling pathway

adenylate cyclase-activating dopamine receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

negative regulation of adenylate cyclase activity

1 reference

1 January 2018

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33535&geneProductId=UniProtKB:P33535

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

neuropeptide signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model

response to radiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

sensory perception of pain

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

adenylate cyclase-inhibiting opioid receptor signaling pathway

1 reference

14 February 2019

Integrins regulate opioid receptor signaling in trigeminal ganglion neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

positive regulation of appetite

1 reference

14 February 2019

A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

response to lipopolysaccharide

1 reference

14 February 2019

Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

G protein-coupled opioid receptor signaling pathway

1 reference

14 February 2019

Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

negative regulation of cAMP-mediated signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

negative regulation of nitric oxide biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

1 reference

14 February 2019

Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

behavioral response to ethanol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

negative regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

regulation of sensory perception of pain

ISS

3 references

14 February 2019

Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

14 February 2019

kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

excitatory postsynaptic potential

1 reference

14 February 2019

Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

calcium ion transmembrane transport

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

response to growth factor

1 reference

14 February 2019

Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

cellular response to morphine

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

regulation of cellular response to stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

regulation of NMDA receptor activity

1 reference

14 February 2019

Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

1 reference

14 February 2019

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0