Transforming growth factor, beta receptor 2 (Q28561037)

transforming growth factor-beta receptor, type II

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Transforming growth factor beta receptor 2 ectodomain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

protein kinase activity

1 reference

14 February 2019

protein serine/threonine kinase activity

transforming growth factor beta receptor activity, type II

2 references

4 references

14 February 2019

Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

4 references

14 February 2019

Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

2 references

glycosaminoglycan binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

growth factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

mitogen-activated protein kinase kinase kinase binding

IBA

1 reference

14 February 2019

A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

signaling receptor activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

protein homodimerization activity

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

2 references

protein heterodimerization activity

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

transforming growth factor beta binding

TAS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

2 references

external side of plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

2 references

integral component of membrane

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

branching involved in blood vessel morphogenesis

IDA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

in utero embryonic development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of mesenchymal cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

lens development in camera-type eye

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of tolerance induction to self antigen

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of B cell tolerance induction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of T cell tolerance induction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

outflow tract septum morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

membranous septum morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

outflow tract morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

atrioventricular valve morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

tricuspid valve morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

cardiac left ventricle morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

endocardial cushion fusion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

growth plate cartilage development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

growth plate cartilage chondrocyte growth

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

protein phosphorylation

2 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

receptor-mediated endocytosis

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

2 references

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

transforming growth factor beta receptor signaling pathway

5 references

14 February 2019

Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

common-partner SMAD protein phosphorylation

IBA

1 reference

14 February 2019

Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

IDA

Notch signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

smoothened signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

pattern specification process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Gene expression of transforming growth factor-beta receptors types I and II in rat endometrium during the estrous cycle and early pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Transforming growth factor-beta(s) and their receptors in aging rat prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

negative regulation of cell population proliferation

IGI

response to mechanical stimulus

2 references

1 reference

14 February 2019

TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

animal organ morphogenesis

1 reference

14 February 2019

Transforming growth factor beta2, but not beta1 and beta3, is critical for early rat lung branching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

response to organic substance

1 reference

14 February 2019

Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of epithelial cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

response to organic cyclic compound

1 reference

14 February 2019

Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

peptidyl-serine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

peptidyl-threonine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

animal organ regeneration

1 reference

14 February 2019

Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

activation of protein kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

embryonic hemopoiesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

myeloid dendritic cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of skeletal muscle tissue regeneration

1 reference

14 February 2019

The adaptive response of transforming growth factor-beta 2 and -beta RII in the overloaded, regenerating and denervated muscles of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

Estrogen induces apoptosis in a rat prostatic adenocarcinoma: association with an increased expression of TGF-beta 1 and its type-I and type-II receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

response to steroid hormone

1 reference

14 February 2019

Expression of transforming growth factor-beta receptor type I and type II in rat ventral prostate and Dunning R3327 PAP adenocarcinoma in response to castration and oestrogen treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

digestive tract development

1 reference

14 February 2019

Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

embryonic cranial skeleton morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of NK T cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

cartilage development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

negative regulation of cardiac muscle cell proliferation

1 reference

14 February 2019

Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

pathway-restricted SMAD protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

ventricular septum morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

bronchus morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

trachea morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

mammary gland morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

lung lobe morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

secondary palate development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

response to cholesterol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

inferior endocardial cushion morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

lens fiber cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

positive regulation of CD4-positive, alpha-beta T cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38438

Transforming growth factor beta receptor 2 ectodomain

has part(s)

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase domain

1 reference