SHC adaptor protein 1 (Q28559554)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Rattus norvegicus

SHC (Src homology 2 domain containing) transforming protein 1
SHC-transforming protein 1
SH2 domain protein C1
src homology 2 domain-containing-transforming protein C1
Shc1

Language	Label	Description	Also known as
English	SHC adaptor protein 1	mammalian protein found in Rattus norvegicus	SHC (Src homology 2 domain containing) transforming protein 1 SHC-transforming protein 1 SH2 domain protein C1 src homology 2 domain-containing-transforming protein C1 Shc1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

SHC-transforming protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5M824

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5M824

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5M824

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphotyrosine interaction domain, Shc-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 adaptor protein C, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTB/PI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphotyrosine residue binding

determination method

1 reference

14 February 2019

Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

epidermal growth factor receptor binding

determination method

1 reference

14 February 2019

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

protein binding

determination method

3 references

14 February 2019

Shc and CEACAM1 interact to regulate the mitogenic action of insulin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

receptor tyrosine kinase binding

determination method

3 references

14 February 2019

Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

protein-containing complex binding

determination method

phosphoprotein binding

determination method

1 reference

14 February 2019

Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

protein phosphatase 2A binding

determination method

determination method

1 reference

14 February 2019

Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

endosome membrane

determination method

1 reference

14 February 2019

Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

Shc-EGFR complex

determination method

1 reference

14 February 2019

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

biological process

determination method

2 references

response to hypoxia

determination method

1 reference

14 February 2019

p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

regulation of smooth muscle contraction

determination method

1 reference

14 February 2019

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

epidermal growth factor receptor signaling pathway

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

determination method

1 reference

14 February 2019

Effects of age on elements of insulin-signaling pathway in central nervous system of rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

insulin receptor signaling pathway

determination method

3 references

14 February 2019

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to toxic substance

determination method

1 reference

14 February 2019

Distinct signaling functions for Shc isoforms in the heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to organic cyclic compound

determination method

1 reference

14 February 2019

Distinct signaling functions for Shc isoforms in the heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

actin cytoskeleton organization

determination method

1 reference

14 February 2019

Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

neuron differentiation

determination method

1 reference

14 February 2019

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

animal organ regeneration

determination method

1 reference

14 February 2019

Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

neuron projection development

determination method

1 reference

14 February 2019

ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to insulin

determination method

1 reference

14 February 2019

Effects of age on elements of insulin-signaling pathway in central nervous system of rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

cellular response to insulin stimulus

determination method

1 reference

14 February 2019

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to nicotine

determination method

1 reference

14 February 2019

Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

intracellular signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

regulation of growth

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to hydrogen peroxide

determination method

1 reference

14 February 2019

Distinct signaling functions for Shc isoforms in the heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

positive regulation of vasoconstriction

determination method

1 reference

14 February 2019

P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

14 February 2019

The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to glucocorticoid

determination method

1 reference

14 February 2019

Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

cellular response to growth factor stimulus

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

response to endothelin

determination method

1 reference

14 February 2019

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000028038

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000028038

ENSRNOP00000053490

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000053490

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28559554&oldid=2023073866"