Raf-1 proto-oncogene, serine/threonine kinase (Q28558646)

Protein kinase-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

Raf-like Ras-binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

protein kinase activity

1 reference

14 February 2019

protein serine/threonine kinase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

MAP kinase kinase kinase activity

IBA

5 references

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Regulation and role of Raf-1/B-Raf heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Insulin enhances growth hormone induction of the MEK/ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

4 references

14 February 2019

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

adenylate cyclase binding

1 reference

14 February 2019

Raf kinase activation of adenylyl cyclases: isoform-selective regulation

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

adenylate cyclase activator activity

IPI

1 reference

14 February 2019

Raf kinase activation of adenylyl cyclases: isoform-selective regulation

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

mitogen-activated protein kinase kinase binding

1 reference

14 February 2019

Regulation and role of Raf-1/B-Raf heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

identical protein binding

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

protein heterodimerization activity

1 reference

14 February 2019

Regulation and role of Raf-1/B-Raf heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

3 references

14 February 2019

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

cellular glucose homeostasis

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

positive regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

protein phosphorylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Regulation and role of Raf-1/B-Raf heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

14 February 2019

Insulin enhances growth hormone induction of the MEK/ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

activation of adenylate cyclase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

negative regulation of cell population proliferation

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

thyroid gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

negative regulation of protein-containing complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

positive regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

somatic stem cell population maintenance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

insulin secretion involved in cellular response to glucose stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

response to muscle stretch

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

negative regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

intermediate filament cytoskeleton organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

neurotrophin TRK receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

death-inducing signaling complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11345

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

diacylglycerol/phorbol-ester binding

1 reference

protein kinase domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

Raf-like Ras-binding

1 reference