Jun proto-oncogene, AP-1 transcription factor subunit (Q28558631)

Transcription Factor c-Jun/v-Jun

1 reference

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Jun-like transcription factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

double-stranded DNA binding

3 references

8 April 2019

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

DNA-binding transcription factor activity

3 references

8 April 2019

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

GTPase activator activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

transcription factor binding

3 references

8 April 2019

A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

ubiquitin protein ligase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cAMP response element binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

identical protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

protein homodimerization activity

3 references

8 April 2019

c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Modulation of cellular AP-1 DNA binding activity by heat shock proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

sequence-specific DNA binding

4 references

8 April 2019

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

ubiquitin-like protein ligase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

protein heterodimerization activity

4 references

8 April 2019

c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Modulation of cellular AP-1 DNA binding activity by heat shock proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

HMG box domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

transcription repressor complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

transcription factor AP-1 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of transcription by RNA polymerase II

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

microglial cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

release of cytochrome c from mitochondria

1 reference

8 April 2019

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

transcription, DNA-templated

1 reference

8 April 2019

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

transcription by RNA polymerase II

transforming growth factor beta receptor signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

Sequence-specific impairment of learning by c-jun antisense oligonucleotides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of cell population proliferation

1 reference

8 April 2019

Identification of c-Jun as a critical mediator for the intracrine 24 kDa FGF-2 isoform-induced cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

response to organic substance

positive regulation of epithelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

response to organic cyclic compound

1 reference

8 April 2019

The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

monocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of protein autophosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cellular response to hormone stimulus

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cellular response to reactive oxygen species

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

leading edge cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

response to muscle stretch

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

response to hydrogen peroxide

1 reference

8 April 2019

H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of neuron apoptotic process

3 references

8 April 2019

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of GTPase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation by host of viral transcription

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation by host of viral transcription

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of monocyte differentiation

1 reference

8 April 2019

Differentiation of WEHI-3B D+ myelomonocytic leukemia cells induced by ectopic expression of the protooncogene c-jun

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of DNA replication

1 reference

8 April 2019

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of fibroblast proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cellular response to potassium ion starvation

1 reference

8 April 2019

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells

membrane depolarization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

SMAD protein signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

eyelid development in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cellular response to cadmium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

cellular response to calcium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

positive regulation of DNA-templated transcription, initiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325

Jun-like transcription factor domain

has part(s)

1 reference

Basic-leucine zipper domain

1 reference