Parkin RBR E3 ubiquitin protein ligase (Q28558502)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

G protein-coupled receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

ubiquitin-protein transferase activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein-containing complex binding

1 reference

14 February 2019

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

ubiquitin protein ligase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cullin family protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

endoplasmic reticulum

3 references

14 February 2019

14 February 2019

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

endoplasmic reticulum membrane

1 reference

14 February 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

synaptic vesicle membrane

1 reference

14 February 2019

Parkin is associated with cellular vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

3 references

14 February 2019

Cloning of rat parkin cDNA and distribution of parkin in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

postsynaptic membrane

1 reference

14 February 2019

perinuclear region of cytoplasm

1 reference

14 February 2019

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

intracellular vesicle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

Parkin-FBXW7-Cul1 ubiquitin ligase complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

biological process

mitochondrial fission

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

autophagy of mitochondrion

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein monoubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

response to oxidative stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

response to unfolded protein

1 reference

14 February 2019

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

mitochondrion organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

adult locomotory behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

regulation of gene expression

1 reference

14 February 2019

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

regulation of autophagy

1 reference

14 February 2019

positive regulation of mitochondrial fusion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of mitochondrial fusion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of mitochondrial membrane potential

1 reference

14 February 2019

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

response to muscle activity

1 reference

14 February 2019

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein ubiquitination

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

14 February 2019

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of glucokinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

response to endoplasmic reticulum stress

1 reference

14 February 2019

Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

14 February 2019

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

regulation of apoptotic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of apoptotic process

1 reference

14 February 2019

Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

mitochondrial fragmentation involved in apoptotic process

1 reference

14 February 2019

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of JNK cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of insulin secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

response to corticosterone

1 reference

14 February 2019

Regulation of hippocampal parkin protein by corticosteroids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

mitochondrion localization

1 reference

14 February 2019

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein autoubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

neuron cellular homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein K63-linked ubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein K48-linked ubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein K11-linked ubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cellular response to manganese ion

1 reference

14 February 2019

Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

protein K6-linked ubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of mitochondrial fission

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of release of cytochrome c from mitochondria

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of mitochondrial fission

1 reference

14 February 2019

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of excitatory postsynaptic potential

1 reference

14 February 2019

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cellular response to toxic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of neuron death

1 reference

14 February 2019

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of mitophagy

IGI

1 reference

14 February 2019

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of oxidative stress-induced neuron death

1 reference

14 February 2019

ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of tumor necrosis factor-mediated signaling pathway

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of reactive oxygen species biosynthetic process

1 reference

14 February 2019

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

14 February 2019

Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cellular response to L-glutamine

1 reference

14 February 2019

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cellular response to hydrogen sulfide

1 reference

14 February 2019

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

cellular response to L-glutamate

1 reference

14 February 2019

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

negative regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

positive regulation of ATP biosynthetic process

1 reference

14 February 2019

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9JK66

IBR domain

1 reference

stated in

InterPro Release 71.0