Insulin-like growth factor binding protein 3 (Q28557491)

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mammalian protein found in Rattus norvegicus

Igfbp3
insulin-like growth factor-binding protein (IGF-BP3)
IBP-3
IGFBP-3
IGF-binding protein 3
insulin-like growth factor-binding protein 3

Language	Label	Description	Also known as
English	Insulin-like growth factor binding protein 3	mammalian protein found in Rattus norvegicus	Igfbp3 insulin-like growth factor-binding protein (IGF-BP3) IBP-3 IGFBP-3 IGF-binding protein 3 insulin-like growth factor-binding protein 3

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Thyroglobulin type-1 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Insulin-like growth factor binding protein 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Thyroglobulin type-1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Insulin-like growth factor-binding protein, IGFBP family

1 reference

based on heuristic

inferred from protein domain or family

Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

fibronectin binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

protein binding

determination method

1 reference

14 February 2019

Binding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

insulin-like growth factor binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

protein tyrosine phosphatase activator activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

growth factor binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

insulin-like growth factor I binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

insulin-like growth factor II binding

determination method

extracellular region

determination method

2 references

extracellular space

determination method

3 references

14 February 2019

A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

14 February 2019

Growth factors and glucose homeostasis in diabetic rats: effects of exercise training

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

platelet alpha granule

determination method

1 reference

14 February 2019

Megakaryocytes endocytose insulin-like growth factor (IGF) I and IGF-binding protein-3: a novel mechanism directing them into alpha granules of platelets

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

insulin-like growth factor ternary complex

determination method

1 reference

14 February 2019

Binding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

insulin-like growth factor binary complex

determination method

1 reference

14 February 2019

Binding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

biological process

response to hypoxia

determination method

1 reference

14 February 2019

Study on intermittent hypoxia in children sleep apnea hypopnea syndrome model and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in serum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

female pregnancy

determination method

1 reference

14 February 2019

Megakaryocytes endocytose insulin-like growth factor (IGF) I and IGF-binding protein-3: a novel mechanism directing them into alpha granules of platelets

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

negative regulation of cell population proliferation

determination method

1 reference

14 February 2019

Role of IGFBP-3 in the regulation of β-cell mass during obesity: adipose tissue/β-cell cross talk

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

positive regulation of cardiac muscle cell apoptotic process

determination method

1 reference

14 February 2019

Insulin-like growth factor binding protein-3 mediates serum starvation- and doxorubicin-induced apoptosis in H9c2 cardiac cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

response to lipopolysaccharide

determination method

1 reference

14 February 2019

Dexamethasone administration attenuates the inhibitory effect of lipopolysaccharide on IGF-I and IGF-binding protein-3 in adult rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

response to insulin

determination method

1 reference

14 February 2019

Insulin and insulin-like growth factor-I regulate hepatic insulin-like growth factor binding protein-3 by different mechanisms

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

regulation of insulin-like growth factor receptor signaling pathway

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

regulation of phosphoprotein phosphatase activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

positive regulation of myoblast differentiation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

response to growth hormone

determination method

1 reference

14 February 2019

Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

response to caloric restriction

determination method

1 reference

14 February 2019

Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

cellular response to estradiol stimulus

determination method

1 reference

14 February 2019

Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

positive regulation of apoptotic DNA fragmentation

determination method

1 reference

14 February 2019

Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

cellular response to Thyroglobulin triiodothyronine

determination method

1 reference

14 February 2019

Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

response to insulin-like growth factor stimulus

determination method

1 reference

14 February 2019

Insulin and insulin-like growth factor-I regulate hepatic insulin-like growth factor binding protein-3 by different mechanisms

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

negative regulation of testosterone secretion

determination method

1 reference

14 February 2019

Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated decreased testosterone concentrations in diabetic rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15473

determination method

Insulin-like growth factor-binding protein, IGFBP

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Thyroglobulin type-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15473

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000073137

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000073137

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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