Kynurenine 3-monooxygenase (Q28557333)

http://www.ebi.ac.uk/interpro/protein/O88867

FAD/NAD(P)-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88867

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FAD-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

monooxygenase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

kynurenine 3-monooxygenase activity

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Effect of branched chain alpha-keto acids on kynurenine 3-hydroxylase from rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Presence of Kynurenine Hydroxylase in Developing Rat Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

NAD(P)H oxidase H2O2-forming activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

oxidoreductase activity

1 reference

14 February 2019

flavin adenine dinucleotide binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

3 references

1 reference

14 February 2019

Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

mitochondrial outer membrane

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Effect of branched chain alpha-keto acids on kynurenine 3-hydroxylase from rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

mitochondrial membranes

1 reference

14 February 2019

tryptophan catabolic process

biological process

2 references

1 reference

14 February 2019

The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

NAD biosynthetic process

1 reference

14 February 2019

response to salt stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

positive regulation of glutamate secretion

1 reference

14 February 2019

Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

pyridine nucleotide biosynthetic process

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

NAD metabolic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

quinolinate biosynthetic process

response to lipopolysaccharide

2 references

1 reference

14 February 2019

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

kynurenic acid biosynthetic process

1 reference

14 February 2019

Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

'de novo' NAD biosynthetic process from tryptophan

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

anthranilate metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

kynurenine metabolic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

cellular response to lipopolysaccharide

1 reference

14 February 2019

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

cellular response to interleukin-1

1 reference

14 February 2019

Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

L-kynurenine metabolic process

1 reference

14 February 2019

Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

positive regulation of neuron death

IDA

1 reference

14 February 2019

Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

positive regulation of glutamate secretion, neurotransmission

IMP

1 reference

14 February 2019

Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88867

1 reference

InterPro Release 71.0