Phospholipase C, gamma 1 (Q28556420)

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mammalian protein found in Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
PLC-148
phosphoinositide phospholipase C-gamma-1
PLC-II
PLC-gamma-1
phosphoinositide phospholipase C
Plcg1

Language	Label	Description	Also known as
English	Phospholipase C, gamma 1	mammalian protein found in Rattus norvegicus	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLC-148 phosphoinositide phospholipase C-gamma-1 PLC-II PLC-gamma-1 phosphoinositide phospholipase C Plcg1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLC-gamma, C-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLC-gamma, N-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphatidylinositol phospholipase C activity

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

insulin receptor binding

determination method

1 reference

14 February 2019

Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

calcium ion binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

protein binding

determination method

11 references

14 February 2019

TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

phosphoric diester hydrolase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

phosphoprotein binding

determination method

1 reference

14 February 2019

Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

determination method

2 references

determination method

1 reference

14 February 2019

Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

plasma membrane

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686

determination method

COP9 signalosome

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

determination method

2 references

clathrin-coated vesicle

determination method

1 reference

14 February 2019

AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

cell projection

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

neuron projection

determination method

1 reference

14 February 2019

Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

biological process

lipid metabolism

determination method

2 references

signal transduction

determination method

3 references

14 February 2019

Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

protein secretion

determination method

1 reference

14 February 2019

Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

phospholipid catabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

response to gravity

determination method

1 reference

14 February 2019

Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

response to organonitrogen compound

determination method

1 reference

14 February 2019

Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

lipid catabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

inositol trisphosphate biosynthetic process

determination method

1 reference

1 January 2018

Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686

determination method

intracellular signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

response to hydrogen peroxide

determination method

1 reference

14 February 2019

Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

response to morphine

determination method

1 reference

14 February 2019

Regulation of neuronal PLCgamma by chronic morphine

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

cellular response to epidermal growth factor stimulus

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

regulation of store-operated calcium channel activity

determination method

1 reference

14 February 2019

Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

calcium ion transport

determination method

1 reference

14 February 2019

Phospholipase C-gamma is required for agonist-induced Ca2+ entry

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

phosphatidylinositol-mediated signaling

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

release of sequestered calcium ion into cytosol

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

EF-hand 1, calcium-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

PLC-gamma, N-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

PLC-gamma, C-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10686

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000069822

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000069822

ENSRNOP00000091002

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000091002

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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