Platelet-activating factor receptor (Q28555962)

http://www.ebi.ac.uk/interpro/protein/P46002

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

lipopolysaccharide binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

lipopolysaccharide immune receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

G protein-coupled receptor activity

platelet activating factor receptor activity

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

1 reference

14 February 2019

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

G protein-coupled purinergic nucleotide receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

mitogen-activated protein kinase binding

IBA

1 reference

14 February 2019

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

integral component of membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of cellular extravasation

2 references

14 February 2019

(+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

2 references

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

G protein-coupled receptor signaling pathway

5 references

14 February 2019

Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

1 reference

14 February 2019

Prolongation of Parturition in the Pregnant Rat Following Treatment with a Platelet Activating Factor Receptor Antagonist1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

response to symbiotic bacterium

1 reference

14 February 2019

Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of phospholipase C activity

1 reference

14 February 2019

The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

lipopolysaccharide-mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. Prevention by PAF receptor antagonists and lipoxygenase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

inositol trisphosphate biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

G protein-coupled purinergic nucleotide receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of neutrophil degranulation

1 reference

14 February 2019

(+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

1 reference

14 February 2019

Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of translation

1 reference

14 February 2019

Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

negative regulation of blood pressure

positive regulation of vasoconstriction

2 references

14 February 2019

Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of smooth muscle contraction

1 reference

14 February 2019

Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

response to organophosphorus

1 reference

14 February 2019

cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

phosphatidylinositol-mediated signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of inositol phosphate biosynthetic process

1 reference

14 February 2019

The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

cellular response to gravity

1 reference

14 February 2019

Platelet-activating factor receptor signals in rat osteoblasts during spaceflight

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

cellular response to cAMP

1 reference

14 February 2019

Regulation of platelet-activating factor receptor and platelet-activating factor receptor-mediated biological responses by cAMP in rat Kupffer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

cellular response to fatty acid

1 reference

14 February 2019

Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

response to dexamethasone

1 reference

14 February 2019

Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of voltage-gated chloride channel activity

1 reference

14 February 2019

Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of leukocyte cell-cell adhesion

1 reference

14 February 2019

Influence of the platelet-activating factor receptor antagonist BN52021 on endotoxin-induced leukocyte adherence in rat mesenteric venules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of leukocyte tethering or rolling

1 reference

14 February 2019

Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of sensory perception of pain

1 reference

14 February 2019

Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of transcytosis

1 reference

14 February 2019

Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of maternal process involved in parturition

1 reference

14 February 2019

Prolongation of Parturition in the Pregnant Rat Following Treatment with a Platelet Activating Factor Receptor Antagonist1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

positive regulation of gastro-intestinal system smooth muscle contraction

1 reference

14 February 2019

Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine

1 reference

14 February 2019

Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine

1 reference

14 February 2019

cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46002

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0