Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells (Q28542653)

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Language	Label	Description	Also known as
English	Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells	scientific article

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scholarly article

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Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells (English)

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1 reference

based on heuristic

inferred from title

pancreatic cancer

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based on heuristic

inferred from title

author name string

Ming Ming

1

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James Sinnett-Smith

2

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Jia Wang

3

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Heloisa P Soares

4

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Steven H Young

5

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Guido Eibl

6

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Enrique Rozengurt

7

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language of work or name

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publication date

2014

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9

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e114573

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12

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copyright license

Creative Commons Attribution 4.0 International

10 December 2014

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April 2022 Public Data File from Crossref

copyright status

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Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment

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Cancer statistics, 2014

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19 March 2017

MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth

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Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice

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Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis

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19 March 2017

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study

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Gestational diabetes as a risk factor for pancreatic cancer: a prospective cohort study

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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TSC2 mediates cellular energy response to control cell growth and survival

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Role of AMP-activated protein kinase in mechanism of metformin action

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders

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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

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Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.

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29 September 2017

Metformin--mode of action and clinical implications for diabetes and cancer

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29 September 2017

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

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AMPK: a contextual oncogene or tumor suppressor?

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Metformin inhibits the growth of human pancreatic cancer xenografts

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29 September 2017

Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells

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Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells

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AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

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Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

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29 September 2017

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

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29 September 2017

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

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29 September 2017

Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells

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Metformin use is associated with better survival of diabetic patients with pancreatic cancer

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29 September 2017

Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression.

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Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

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Mitochondrial dysfunction links ceramide activated HRK expression and cell death

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Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca²+ oscillations in pancreatic cancer PANC-1 cells

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Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer

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Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states

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Insulin-lowering effects of metformin in women with early breast cancer

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21 January 2018

Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine

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21 January 2018

Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice

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21 January 2018

AMPK is a direct adenylate charge-regulated protein kinase.

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21 January 2018

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

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21 January 2018

Consumption of sugar and sugar-sweetened foods and the risk of pancreatic cancer in a prospective study

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Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma

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12 December 2020

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inferred from PubMed ID database lookup

Acute toxicity of berberine and its correlation with the blood concentration in mice

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Anthropometry and Pancreatic Cancer Risk: An Illustration of the Importance of Microscopic Verification

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based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0114573

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Consolidated OpenCitations Corpus – April 2017

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2014PLoSO...9k4573M

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1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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