Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells (Q28534922)

1

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Tetsuhiro Chiba

2

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Kaori Yuki

3

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Yoh Zen

4

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Motohiko Oshima

5

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Shuhei Koide

6

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Tenyu Motoyama

7

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Sadahisa Ogasawara

8

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Eiichiro Suzuki

9

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Yoshihiko Ooka

10

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Akinobu Tawada

11

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Motohisa Tada

12

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Fumihiko Kanai

13

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Yuichi Takiguchi

14

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Osamu Yokosuka

Creative Commons Attribution 4.0 International

16

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language of work or name

English

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publication date

2013

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published in

PLOS One

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volume

8

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issue

7

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page(s)

e70010

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copyright license

start time

29 July 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Sorafenib in advanced hepatocellular carcinoma

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Role of AMP-activated protein kinase in mechanism of metformin action

19 March 2017

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Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

19 March 2017

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

7 April 2017

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Metformin and reduced risk of cancer in diabetic patients

7 April 2017

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The mTOR pathway in hepatic malignancies

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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

29 September 2017

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Metformin targets ovarian cancer stem cells in vitro and in vivo

29 September 2017

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Clinical implications of cancer stem cell biology in hepatocellular carcinoma

29 September 2017

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Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

29 September 2017

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Phase 1/2 study of everolimus in advanced hepatocellular carcinoma

29 September 2017

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Metformin: taking away the candy for cancer?

29 September 2017

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

29 September 2017

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Rapamycin inhibits proliferation and migration of hepatoma cells in vitro

29 September 2017

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EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

29 September 2017

1 reference

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Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.

29 September 2017

1 reference

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Pivotal role of mTOR signaling in hepatocellular carcinoma

29 September 2017

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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

29 September 2017

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Human hepatic stem cells from fetal and postnatal donors

29 September 2017

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Identification and characterization of tumorigenic liver cancer stem/progenitor cells

29 September 2017

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Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

29 September 2017

1 reference

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Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726625

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070010

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070010

In vitro and in vivo antitumoral action of metformin on hepatocellular carcinoma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070010

Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23922888

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922888

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0070010

1 reference

1015909

ADS bibcode

2013PLoSO...870010S

0 references

1015909

1 reference

1 reference

1 reference