Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate (Q28482284)

1

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Svetlana Gerdes

2

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Christopher Holbrook

3

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Donald C Liu

4

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Olga Y Zaborina

5

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John C Alverdy

Creative Commons Attribution 4.0 International

6

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

4

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page(s)

e34883

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copyright license

start time

13 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis

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Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa

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The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa

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Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry

19 March 2017

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The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones

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Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication

19 March 2017

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Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration

7 April 2017

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Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda

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Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH.

29 September 2017

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Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes

29 September 2017

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LuxR homolog-independent gene regulation by acyl-homoserine lactones in Pseudomonas aeruginosa.

29 September 2017

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Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts

29 September 2017

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Homeostatic interplay between bacterial cell-cell signaling and iron in virulence

29 September 2017

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Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils

29 September 2017

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Development of peripheral opioid antagonists' new insights into opioid effects

29 September 2017

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PqsE functions independently of PqsR-Pseudomonas quinolone signal and enhances the rhl quorum-sensing system.

29 September 2017

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29 September 2017

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Phenazines and other redox-active antibiotics promote microbial mineral reduction.

29 September 2017

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Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis

29 September 2017

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PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.

2 June 2018

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Contamination of hospital curtains with healthcare-associated pathogens

2 June 2018

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A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules.

21 January 2018

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Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules.

21 January 2018

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The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.

21 January 2018

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The human microbiome harbors a diverse reservoir of antibiotic resistance genes.

21 January 2018

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Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa.

21 January 2018

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The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR.

21 January 2018

1 reference

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Severe hypophosphatemia in sepsis as a mortality predictor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22514685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22514685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of multidrug-resistant pathogens in health-care-associated pneumonia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22514685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0034883

1 reference

4319273

ADS bibcode

2012PLoSO...734883Z

0 references

4319273

1 reference

1 reference

1 reference