The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor (Q28475670)

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15 February 2020

title

The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor (English)

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15 February 2020

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2

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10

Robert L Tanguay

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15 February 2020

author name string

Edmond F O'Donnell

1

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15 February 2020

Daniel C Koch

3

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15 February 2020

Prasad R Kopparapu

4

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David Farrer

5

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15 February 2020

William H Bisson

6

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Lijoy K Mathew

7

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15 February 2020

Sumitra Sengupta

8

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Nancy I Kerkvliet

9

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15 February 2020

Siva Kumar Kolluri

11

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language of work or name

English

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publication date

1 October 2010

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15 February 2020

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volume

5

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issue

10

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Creative Commons Attribution 4.0 International

15 February 2020

page(s)

e13128

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copyright license

start time

1 October 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

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Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein

19 March 2017

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2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein tyrosine kinase, pp60src, in murine hepatic cytosol using a cell-free system

19 March 2017

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Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes

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The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis

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Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands

29 September 2017

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Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system

29 September 2017

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The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice.

29 September 2017

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AHR-mediated immunomodulation: the role of altered gene transcription

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Expression and activity of aryl hydrocarbon receptors in development and cancer

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Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish

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29 September 2017

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29 September 2017

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Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine

29 September 2017

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Molecular biology of the Ah receptor and its role in carcinogenesis

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin

29 September 2017

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29 September 2017

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Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest

29 September 2017

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Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor

2 June 2018

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Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.

2 June 2018

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The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice.

27 November 2018

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Aryl hydrocarbon receptor activation inhibits regenerative growth

27 November 2018

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In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2948512

2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration

27 November 2018

1 reference

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Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20957046

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0013128

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957046%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

ADS bibcode

2010PLoSO...513128O

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957046%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

2 references