A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response (Q28471659)

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29 December 2019

title

A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response (English)

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29 December 2019

1 reference

1

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29 December 2019

author name string

Minerva Yue

2

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29 December 2019

Wendy Chung

3

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29 December 2019

Meghan Spyres

4

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29 December 2019

Robert H Pass

5

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29 December 2019

Eric Silver

6

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29 December 2019

Kevin J Sampson

7

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29 December 2019

Robert S Kass

8

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29 December 2019

language of work or name

English

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publication date

5 December 2007

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29 December 2019

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29 December 2019

volume

2

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29 December 2019

issue

12

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29 December 2019

page(s)

e1258

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Creative Commons Attribution 4.0 International

29 December 2019

copyright license

start time

5 December 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Prevalence of long-QT syndrome gene variants in sudden infant death syndrome

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Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

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Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action

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29 September 2017

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A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y

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Long QT syndrome and life threatening arrhythmia in a newborn: molecular diagnosis and treatment response

29 September 2017

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Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG).

29 September 2017

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Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia

29 September 2017

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Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

29 September 2017

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Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

29 September 2017

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Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

29 September 2017

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De novo mutation in the SCN5A gene associated with early onset of sudden infant death

29 September 2017

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Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.

29 September 2017

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A molecular link between the sudden infant death syndrome and the long-QT syndrome

29 September 2017

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Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium

29 September 2017

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Role in fast inactivation of the IV/S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis

29 September 2017

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Pharmacological targeting of long QT mutant sodium channels

29 September 2017

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Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

29 September 2017

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Molecular mechanism for an inherited cardiac arrhythmia

29 September 2017

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KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome

29 September 2017

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Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome

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12 December 2020

Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea-pig ventricular myocytes

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Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

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12 December 2020

10.1371/JOURNAL.PONE.0001258

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060054%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

ADS bibcode

2007PLoSO...2.1258B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060054%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

18060054

2 references