A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance (Q28395203)

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English	A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance	scientific article

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scholarly article

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2 March 2020

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance (English)

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2 March 2020

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multiple myeloma

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based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

Pádraig D'arcy

2

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2 March 2020

Paul G. Richardson

8

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Paul Richardson

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2 March 2020

Kenneth C. Anderson

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Kenneth C Anderson

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2 March 2020

Dharminder Chauhan

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Dharminder Chauhan

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2 March 2020

Ruben Perez-Carrasco

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Ruben D Carrasco

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Arghya Ray

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2 March 2020

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Ze Tian

1

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2 March 2020

Xin Wang

3

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2 March 2020

Yu-Tzu Tai

5

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2 March 2020

Stig Linder

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publication date

6 December 2013

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706-716

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2 March 2020

5

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2 March 2020

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907756

19 March 2017

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

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19 March 2017

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

1 reference

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19 March 2017

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

1 reference

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19 March 2017

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

1 reference

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19 March 2017

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

1 reference

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19 March 2017

Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases

1 reference

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19 March 2017

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

1 reference

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19 March 2017

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

1 reference

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19 March 2017

Arsenite-induced Cdc25C Degradation is through the KEN-box and Ubiquitin-proteasome Pathway

1 reference

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19 March 2017

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

1 reference

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19 March 2017

Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development

1 reference

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19 March 2017

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

1 reference

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7 April 2017

New proteasome inhibitors in myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907756

29 September 2017

Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

1 reference

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29 September 2017

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

1 reference

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29 September 2017

Proteasome deubiquitinases as novel targets for cancer therapy

1 reference

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29 September 2017

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

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29 September 2017

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

1 reference

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29 September 2017

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

1 reference

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29 September 2017

Deubiquitinases in cancer: new functions and therapeutic options.

1 reference

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29 September 2017

In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells

1 reference

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29 September 2017

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

1 reference

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29 September 2017

The therapeutic potential of deubiquitinating enzyme inhibitors

1 reference

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29 September 2017

Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.

1 reference

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DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

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p21 in cancer: intricate networks and multiple activities

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29 September 2017

Reverse the curse--the role of deubiquitination in cell cycle control

1 reference

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29 September 2017

Ubiquitin-mediated activation of TAK1 and IKK.

1 reference

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29 September 2017

Deubiquitinating enzymes as novel anticancer targets

1 reference

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29 September 2017

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

1 reference

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29 September 2017

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

1 reference

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29 September 2017

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

1 reference

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29 September 2017

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

1 reference

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29 September 2017

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

1 reference

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29 September 2017

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

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29 September 2017

Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma

1 reference

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2 June 2018

Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma.

1 reference

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27 November 2018

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

1 reference

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27 November 2018

Identifiers

10.1182/BLOOD-2013-05-500033

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

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2 March 2020

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

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2 March 2020

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