Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2) (Q28391076)

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English	Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)	scientific article

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scholarly article

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Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2) (English)

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author name string

Kevin Schneider

1

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Joshua Valdez

2

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Janice Nguyen

3

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Marquis Vawter

4

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Brandi Galke

5

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Theodore W Kurtz

6

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Jefferson Y Chan

7

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language of work or name

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publication date

1 April 2016

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Journal of Biological Chemistry

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291

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14

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7754-66

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The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Redox regulation by Nrf2: gatekeeping for the basal and diabetes-induced expression of thioredoxin interacting protein

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20 March 2017

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

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The protein kinase IKKepsilon regulates energy balance in obese mice

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20 March 2017

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

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20 March 2017

Identification and importance of brown adipose tissue in adult humans

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20 March 2017

Regulation of glutathione synthesis

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20 March 2017

Activation of Nrf2 in defense against cadmium-induced oxidative stress

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20 March 2017

Protection against Chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association

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20 March 2017

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

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20 March 2017

FGF-21 as a novel metabolic regulator

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20 March 2017

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

20 March 2017

Nrf2-Keap1 defines a physiologically important stress response mechanism

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Nuclear receptor corepressor RIP140 regulates fat accumulation

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20 March 2017

Superoxide activates mitochondrial uncoupling proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

20 March 2017

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

20 March 2017

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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20 March 2017

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

20 March 2017

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

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20 March 2017

Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

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20 March 2017

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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20 March 2017

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

20 March 2017

Functional brown adipose tissue in healthy adults

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7 April 2017

Cold-activated brown adipose tissue in healthy men

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

Unexpected evidence for active brown adipose tissue in adult humans

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7 April 2017

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

7 April 2017

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

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7 April 2017

A method for assessing mitochondrial bioenergetics in whole white adipose tissues.

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Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

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29 September 2017

Adipose tissue browning and metabolic health

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29 September 2017

Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Brown adipose tissue: research milestones of a potential player in human energy balance and obesity.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

The Keap1-Nrf2 system prevents onset of diabetes mellitus

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: Relationship to adiponectin and parameters of metabolic syndrome

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29 September 2017

Pharmacological strategies for targeting BAT thermogenesis.

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UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms in association with obesity susceptibility - a meta-analysis study

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29 September 2017

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding

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29 September 2017

The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome

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29 September 2017

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

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29 September 2017

The genetics of brown adipocyte induction in white fat depots

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29 September 2017

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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29 September 2017

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis

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29 September 2017

Lipid metabolism and body composition in Gclm(-/-) mice

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29 September 2017

Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice

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29 September 2017

The implication of brown adipose tissue for humans

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29 September 2017

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

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29 September 2017

Cellular bioenergetics as a target for obesity therapy

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29 September 2017

Human brown adipose tissue

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29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

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29 September 2017

Reactive oxygen species enhance insulin sensitivity

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29 September 2017

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

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29 September 2017

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

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29 September 2017

Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology

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29 September 2017

Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

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29 September 2017

Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817199

29 September 2017

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29 September 2017

Towards a molecular understanding of adaptive thermogenesis

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29 September 2017

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity

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29 September 2017

Luxuskonsumption, Diet-Induced Thermogenesis and Brown Fat: The Case in Favour

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29 September 2017

Biosensor plates detect mitochondrial physiological regulators and mutations in vivo

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2 June 2018

RIP140-targeted repression of gene expression in adipocytes

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2 June 2018

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.

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21 January 2018

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

Nrf2, a multi-organ protector?

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress.

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

Functional thermogenic beige adipogenesis is inducible in human neck fat.

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https://api.crossref.org/works/10.1074%2FJBC.M115.673756

21 January 2018

Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity.

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21 January 2018

Causes of differences in respiration rate of hepatocytes from mammals of different body mass

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https://pubmed.ncbi.nlm.nih.gov/26841864

12 December 2020

based on heuristic

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Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR

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https://pubmed.ncbi.nlm.nih.gov/26841864

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based on heuristic

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10.1074/JBC.M115.673756

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