CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. (Q28387717)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

4

1 reference

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6 March 2020

author name string

Norman Ertych

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Ailine Stolz

2

1 reference

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6 March 2020

Oliver Valerius

3

1 reference

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6 March 2020

Holger Bastians

5

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

1 reference

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6 March 2020

volume

113

1 reference

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6 March 2020

issue

7

1 reference

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6 March 2020

page(s)

1817-1822

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

BRCA1, a 'complex' protein involved in the maintenance of genomic stability

6 March 2020

cites work

1 reference

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Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

20 March 2017

1 reference

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The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

20 March 2017

1 reference

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

20 March 2017

1 reference

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Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon

20 March 2017

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CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer

20 March 2017

1 reference

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Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

20 March 2017

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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

20 March 2017

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

20 March 2017

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

20 March 2017

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The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation

20 March 2017

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Identification of a RING protein that can interact in vivo with the BRCA1 gene product

20 March 2017

1 reference

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Andromeda: a peptide search engine integrated into the MaxQuant environment

20 March 2017

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Tracking the ends: a dynamic protein network controls the fate of microtubule tips

7 April 2017

1 reference

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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

7 April 2017

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PP6C hotspot mutations in melanoma display sensitivity to Aurora kinase inhibition.

29 September 2017

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Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

29 September 2017

1 reference

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Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763769

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

29 September 2017

1 reference

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BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763769

Mechanisms of BRCA1 tumor suppression

29 September 2017

1 reference

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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

29 September 2017

1 reference

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Microtubule tip-interacting proteins: a view from both ends

29 September 2017

1 reference

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Plus-end-tracking proteins and their interactions at microtubule ends

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763769

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase

29 September 2017

1 reference

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Whole chromosome instability and cancer: a complex relationship

29 September 2017

1 reference

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Aurora-A - a guardian of poles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763769

CHEK2 is a multiorgan cancer susceptibility gene

29 September 2017

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

29 September 2017

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BRCA1 is associated with the centrosome during mitosis.

29 September 2017

1 reference

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The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.

29 September 2017

1 reference

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Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1525129113

Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

21 January 2018

1 reference

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

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Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).

21 January 2018

1 reference

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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26831064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26831064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1525129113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

1 reference

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6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831064%20AND%20SRC:MED&resulttype=core&format=json