Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate (Q28383320)

13

object named as

Guillermo Garcia-Manero

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Michael J. Keating

11

object named as

Michael Keating

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author name string

Yumin Hu

1

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Weiqin Lu

2

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Gang Chen

3

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Hui Zhang

4

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Yu Jia

5

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Yue Wei

6

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Hui Yang

7

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Wan Zhang

8

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Warren Fiskus

9

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Kapil Bhalla

10

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Peng Huang

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress

12

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language of work or name

English

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publication date

14 October 2010

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published in

Blood

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volume

116

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issue

15

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page(s)

2732-41

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cites work

1 reference

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

20 March 2017

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Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

20 March 2017

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

20 March 2017

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

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Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

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Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

29 September 2017

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Redox regulation of cell survival

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Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

29 September 2017

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Histone deacetylase inhibitors: molecular mechanisms of action

29 September 2017

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29 September 2017

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

29 September 2017

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Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

29 September 2017

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Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects

29 September 2017

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Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

29 September 2017

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Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

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Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro

29 September 2017

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Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor

29 September 2017

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The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

2 June 2018

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Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.

27 November 2018

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NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols

27 November 2018

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27 November 2018

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Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

27 November 2018

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Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells

27 November 2018

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Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response

27 November 2018

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Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

27 November 2018

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10.1182/BLOOD-2009-11-256354

27 November 2018

Identifiers

DOI

1 reference

1418263

1418263

1 reference

1 reference

1 reference