Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C (Q28383172)

2

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Yunzhou Shi

3

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Jixin Cheng

4

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Yansheng Du

5

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Wei Zheng

Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1

6

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language of work or name

English

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publication date

September 2010

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published in

NeuroToxicology

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volume

31

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issue

5

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page(s)

524-32

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cites work

1 reference

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Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers

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Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro

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Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1

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Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation

20 March 2017

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Evidence for altered hippocampal volume and brain metabolites in workers occupationally exposed to lead: a study by magnetic resonance imaging and (1)H magnetic resonance spectroscopy

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The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease

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The environment, epigenetics and amyloidogenesis

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New and evolving concepts in the neurotoxicology of lead

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Macromolecules involved in production and metabolism of beta-amyloid at the brain barriers

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100 years and counting: prospects for defeating Alzheimer's disease

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Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment

29 September 2017

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The choroid plexus removes beta-amyloid from brain cerebrospinal fluid

29 September 2017

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Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration

29 September 2017

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Role of Proteolytic Activation of Protein Kinase Cδ in Oxidative Stress-Induced Apoptosis

29 September 2017

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Caspase‐3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration

29 September 2017

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Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus.

29 September 2017

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Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

29 September 2017

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Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

29 September 2017

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Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease

29 September 2017

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Is chronic low-level lead exposure in early life an etiologic factor in Alzheimer's disease?

29 September 2017

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Lead exposure promotes translocation of protein kinase C activities in rat choroid plexus in vitro, but not in vivo

29 September 2017

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Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: the role of the choroid plexus

29 September 2017

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How is protein kinase C activated in CNS.

29 September 2017

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Inhibition of astroglia-induced endothelial differentiation by inorganic lead: a role for protein kinase C

29 September 2017

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Gamma-secretase limits the inflammatory response through the processing of LRP1

29 September 2017

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Amyloid-beta dynamics correlate with neurological status in the injured human brain

2 June 2018

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2 June 2018

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Occupational lead poisoning

2 June 2018

1 reference

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Developmental lead exposure causes spatial learning deficits in adult rats.

2 June 2018

1 reference

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Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus.

2 June 2018

1 reference

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Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

2 June 2018

1 reference

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Does the choroid plexus really protect the brain from lead?

2 June 2018

1 reference

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Lead activates protein kinase C in immature rat brain microvessels

2 June 2018

1 reference

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Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.

2 June 2018

1 reference

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Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.

2 June 2018

1 reference

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Hippocampal protein kinase C activity is reduced in poor spatial learners.

2 June 2018

1 reference

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Choroid plexus protects cerebrospinal fluid against toxic metals

2 June 2018

1 reference

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Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.

2 June 2018

1 reference

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RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease.

27 November 2018

1 reference

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LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

27 November 2018

1 reference

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Neurocognitive impairment in lead-exposed children of Andean lead-glazing workers.

27 November 2018

1 reference

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The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.

27 November 2018

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Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration

27 November 2018

1 reference

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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

27 November 2018

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27 November 2018

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Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

27 November 2018

1 reference

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Lead content of brain tissue in diffuse neurofibrillary tangles with calcification (DNTC): the possibility of lead neurotoxicity.

27 November 2018

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27 November 2018

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Human choroid plexus is an uniquely involved area of the brain in amyloidosis: a histochemical, immunohistochemical and ultrastructural study

27 November 2018

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Inhibition of brain protein kinase C subtypes by lead.

27 November 2018

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Choroid plexus as a protective sink for heavy metals?

27 November 2018

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12 December 2020

Picomolar concentrations of lead stimulate brain protein kinase C

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12 December 2020

Translocation and activation of protein kinase C in striatal neurons in primary culture: relationship to phorbol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release

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12 December 2020

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12 December 2020