Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT (Q28379490)

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English	Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT	scientific article

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Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT (English)

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Mª Ángeles Muñoz-Fernández

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M A Muñoz-Fernández

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author name string

J Navarro

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C Punzón

2

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J L Jiménez

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E Fernández-Cruz

4

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A Pizarro

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M Fresno

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language of work or name

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publication date

June 1998

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Journal of Virology

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72

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6

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4712-20

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Transcription factors of the NFAT family: regulation and function

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20 March 2017

Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells

1 reference

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20 March 2017

The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells

1 reference

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20 March 2017

Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering

1 reference

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20 March 2017

The NF-kappa B and I kappa B proteins: new discoveries and insights

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20 March 2017

Pathogenesis of human immunodeficiency virus infection

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20 March 2017

NF-AT components define a family of transcription factors targeted in T-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109998

20 March 2017

Multiple cyclic nucleotide phosphodiesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109998

20 March 2017

Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1

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Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes

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Characterization of antigen receptor response elements within the interleukin-2 enhancer

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20 March 2017

Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat

1 reference

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20 March 2017

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1

1 reference

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20 March 2017

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

1 reference

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20 March 2017

Cellular transcription factors involved in the regulation of HIV-1 gene expression

1 reference

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20 March 2017

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription

1 reference

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20 March 2017

A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells

1 reference

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20 March 2017

Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

1 reference

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20 March 2017

Function and activation of NF-kappa B in the immune system

1 reference

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7 April 2017

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1 reference

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7 April 2017

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1 reference

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7 April 2017

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B

1 reference

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Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

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29 September 2017

Host factors and the pathogenesis of HIV-induced disease

1 reference

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29 September 2017

Interleukin-10-induced HIV-1 expression is mediated by induction of both membrane-bound tumour necrosis factor (TNF)-alpha and TNF receptor type 1 in a promonocytic cell line.

1 reference

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Immunosuppressive retroviral peptides: cAMP and cytokine patterns

1 reference

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The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells

1 reference

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29 September 2017

The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus

1 reference

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Immune modulation in HIV infection: fact or fantasy?

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29 September 2017

Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system

1 reference

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29 September 2017

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1 reference

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In vivo footprinting analysis of constitutive and inducible protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1.

1 reference

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29 September 2017

Regulation of human immunodeficiency virus infection: implications for pathogenesis

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29 September 2017

Cyclic AMP inhibits phosphatidylinositol-coupled and -uncoupled mitogenic signals in T lymphocytes. Evidence that cAMP alters PKC-induced transcription regulation of members of the jun and fos family of genes.

1 reference

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Signal transmission between the plasma membrane and nucleus of T lymphocytes

1 reference

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Pentoxifylline for the treatment of infection with human immunodeficiency virus

1 reference

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29 September 2017

The Th1-Th2 hypothesis of HIV infection: new insights

1 reference

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Cytokine modulation of HIV expression

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Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression

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Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat

1 reference

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Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes

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29 September 2017

Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.

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29 September 2017

Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506

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Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation

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Pentoxifylline inhibits acute HIV-1 replication in human T cells by a mechanism not involving inhibition of tumour necrosis factor synthesis or nuclear factor-kappa B activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109998

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Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109998

2 June 2018

ETS family proteins activate transcription from HIV-1 long terminal repeat

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Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

1 reference

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2 June 2018

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2 June 2018

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1 reference

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Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.

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2 June 2018

HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes

1 reference

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2 June 2018

Tumour necrosis factors (alpha, beta) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication.

1 reference

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2 June 2018

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

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2 June 2018

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

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2 June 2018

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1 reference

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Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109998

27 November 2018

Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus

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27 November 2018

In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor

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Overexpression of mitogen-activated protein kinase kinase kinase reversed cAMP inhibition of NF-kappaB in T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9573235

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Physiologic activation of T cells via the T cell receptor induces NF-kappa B

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1 reference

https://pubmed.ncbi.nlm.nih.gov/9573235

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Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs

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12 December 2020

based on heuristic

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