Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers (Q28377159)

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English	Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers	scientific article

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scholarly article

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8 December 2019

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers (English)

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8 December 2019

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Juan Segura-Aguilar

3

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8 December 2019

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S D Raeissi

1

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8 December 2019

I J Hidalgo

2

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8 December 2019

P Artursson

4

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8 December 2019

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1 May 1999

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8 December 2019

Pharmaceutical Research

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8 December 2019

16

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8 December 2019

625-632

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8 December 2019

5

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8 December 2019

CYP3A gene expression in human gut epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and biotransformation studies of terfenadine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P450 mRNAs in the colon and the rectum in normal human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

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inferred from PubMed ID database lookup

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

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Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Jejunal absorption and metabolism of R/S-verapamil in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

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Digoxin biotransformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general pattern for substrate recognition by P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cytochrome P450IA1 gene expression in a human intestinal cell line, Caco-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrates of human hepatic cytochrome P450 3A4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistological evidence, obtained with monoclonal antibodies, of small intestinal brush border hydrolases in human colon cancers and foetal colons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10350002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1018851919674

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10350002%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10350002%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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