PDGFRA FIP1L1::PDGFRA (Q28371530)

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genetic variant

FIP1L1-PDGFRA
FIP1L1::PDGFRA

Language	Label	Description	Also known as
English	PDGFRA FIP1L1::PDGFRA	genetic variant	FIP1L1-PDGFRA FIP1L1::PDGFRA

Statements

transcript fusion

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

human chromosome 4

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

54243812

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

55141008

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

54294350

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

55164414

genomic assembly

Genome assembly GRCh37

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

positive therapeutic predictor for

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

acute myeloid leukemia

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/7378

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

acute myeloid leukemia

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/7378

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

determination method

CIViC evidence level B

CIViC 4-star trust rating

medical condition treated

myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1441

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

determination method

CIViC evidence level A

CIViC 3-star trust rating

medical condition treated

myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1445

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1774

Complete response of monoblastic myeloid sarcoma with FIP1L1- PDGFRA rearrangement to imatinib monotherapy.

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/1777

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/574

Sitelinks

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