Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses (Q28367379)

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19 October 2019

title

Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses (English)

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19 October 2019

2

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19 October 2019

author name string

D M Lowe

1

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19 October 2019

M R Ellis

3

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19 October 2019

V Parmar

4

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19 October 2019

W H Miller

5

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19 October 2019

G B Roberts

6

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19 October 2019

J A Fyfe

7

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19 October 2019

R Gaillard

8

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19 October 2019

P Ertl

9

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19 October 2019

W Snowden

10

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19 October 2019

language of work or name

English

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publication date

1 August 1995

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Antimicrobial Agents and Chemotherapy

19 October 2019

published in

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19 October 2019

volume

39

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19 October 2019

page(s)

1802-1808

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19 October 2019

issue

8

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Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture

19 October 2019

cites work

1 reference

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Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir

20 March 2017

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Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys of (R,S)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine, an anti-varicella-zoster virus drug

20 March 2017

1 reference

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Inhibition of varicella-zoster virus-induced DNA polymerase by a new guanosine analog, 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine triphosphate

20 March 2017

1 reference

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Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds

20 March 2017

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20 March 2017

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6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

20 March 2017

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Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus

20 March 2017

1 reference

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Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

20 March 2017

1 reference

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Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus

7 April 2017

1 reference

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Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells

29 September 2017

1 reference

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Metabolism of acyclovir in virus-infected and uninfected cells

29 September 2017

1 reference

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Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment

29 September 2017

1 reference

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Pharmacokinetics and distribution over the blood brain barrier of two acyclic guanosine analogs in rats, studied by microdialysis

29 September 2017

1 reference

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Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections

29 September 2017

1 reference

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Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus

29 September 2017

1 reference

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Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine

29 September 2017

1 reference

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Varicella-zoster virus thymidine kinase. Characterization and substrate specificity

2 June 2018

1 reference

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Meanings of Ki for conventional and alternate-substrate inhibitors.

27 November 2018

1 reference

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Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus

27 November 2018

1 reference

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Cyclic phosphates of some antiviral acyclonucleosides: relationship between conformation and substrate/inhibitor properties in some enzyme systems

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7486922

12 December 2020

inferred from PubMed ID database lookup

Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7486922

12 December 2020

inferred from PubMed ID database lookup

Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7486922

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/AAC.39.8.1802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7486922%20AND%20SRC:MED&resulttype=core&format=json

release_5tc3ua4xjvechjbupigysqihwi

19 October 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5tc3ua4xjvechjbupigysqihwi

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7486922%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference