Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer (Q28305955)

1

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Andrey Frolov

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Ching-Wei D Tzeng

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Ashley Stewart

4

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Andrew Midzak

5

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Amar Majmundar

6

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Martin Heslin

8

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Alfonso Bellacosa

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J Pablo Arnoletti

Cancer Biology and Therapy

10

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language of work or name

English

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publication date

January 2009

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published in

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volume

8

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page(s)

94-100

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issue

1

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cites work

The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes

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The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity

20 March 2017

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Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis

20 March 2017

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The power and the promise of DNA methylation markers

20 March 2017

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Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

20 March 2017

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The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

20 March 2017

1 reference

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

20 March 2017

1 reference

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CpG island methylator phenotype in colorectal cancer

20 March 2017

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MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

20 March 2017

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Lessons from hereditary colorectal cancer

20 March 2017

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

20 March 2017

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MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

20 March 2017

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Epigenetics and human disease: translating basic biology into clinical applications

20 March 2017

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DNA methylation and human disease

20 March 2017

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

7 April 2017

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

7 April 2017

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Cancer epigenetics comes of age

7 April 2017

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Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

7 April 2017

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DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer

29 September 2017

1 reference

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MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

29 September 2017

1 reference

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MED1: a central molecule for maintenance of genome integrity and response to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Role of MED1 (MBD4) Gene in DNA repair and human cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

X chromosome inactivation and DNA methylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Cellular differentiation, cytidine analogs and DNA methylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Promoter hypermethylation profile of ovarian epithelial neoplasms

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683899

Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19127118

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19127118

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CBT.8.1.7469

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4902248

OpenCitations bibliographic resource ID

4902248

1 reference