Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease (Q28305501)

2

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Cheng Chen

3

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Alba Guarne

4

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Jennifer Surtees

5

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Eric Alani

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

28 February 2014

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published in

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volume

289

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page(s)

5664-73

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issue

9

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cites work

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Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast

20 March 2017

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Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase

20 March 2017

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BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism

20 March 2017

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PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair

20 March 2017

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Structure of the endonuclease domain of MutL: unlicensed to cut.

20 March 2017

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Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination

20 March 2017

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20 March 2017

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hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes

20 March 2017

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A defined human system that supports bidirectional mismatch-provoked excision

20 March 2017

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Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis

20 March 2017

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The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination

20 March 2017

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Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins

20 March 2017

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High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer

20 March 2017

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Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction

20 March 2017

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Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae

20 March 2017

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Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis

20 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A constant rate of spontaneous mutation in DNA-based microbes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Multifunctional yeast high-copy-number shuttle vectors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Meiotic arrest and aneuploidy in MLH3-deficient mice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The functions of MutL in mismatch repair: the power of multitasking

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Genetic analysis of baker's yeast Msh4-Msh5 reveals a threshold crossover level for meiotic viability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A conserved MutS homolog connector domain interface interacts with MutL homologs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Genome-wide redistribution of meiotic double-strand breaks in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Synthetic junctions as tools to identify and characterize Holliday junction resolvases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

From early homologue recognition to synaptonemal complex formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Competing crossover pathways act during meiosis in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

recA protein-catalyzed strand assimilation: stimulation by Escherichia coli single-stranded DNA-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Near-simultaneous DNA cleavage by the subunits of the junction-resolving enzyme T4 endonuclease VII.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937641

Endonucleolytic function of MutLalpha in human mismatch repair.

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Global analysis of the meiotic crossover landscape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Identification of double Holliday junctions as intermediates in meiotic recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Genetic analysis of the mouse brain proteome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

The PMS2 subunit of human MutLalpha contains a metal ion binding domain of the iron-dependent repressor protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Trapping and visualizing intermediate steps in the mismatch repair pathway in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Analysis of the quaternary structure of the MutL C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

Intermediates of Yeast Meiotic Recombination Contain Heteroduplex DNA

21 January 2018

2 references

https://api.crossref.org/works/10.1074%2FJBC.M113.534644

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/24403070