KATP channels as molecular sensors of cellular metabolism (Q28303315)

Roles of KATP channels as metabolic sensors in acute metabolic changes

Europe PubMed Central

title

KATP channels as molecular sensors of cellular metabolism (English)

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author name string

Colin G Nichols

series ordinal

1

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language of work or name

English

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publication date

23 March 2006

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published in

Nature

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volume

440

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issue

7083

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page(s)

470-6

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cites work

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7 January 2021

Toward linking structure with function in ATP-sensitive K+ channels

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7 January 2021

ATP-sensitive potassium channelopathies: focus on insulin secretion

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7 January 2021

Sarcolemmal K(ATP) channels: what do we really know?

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7 January 2021

Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor

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7 January 2021

A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels

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7 January 2021

Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel

1 reference

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7 January 2021

Octameric stoichiometry of the KATP channel complex

1 reference

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7 January 2021

Association and stoichiometry of K(ATP) channel subunits

1 reference

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7 January 2021

Pas de deux in groups of four--the biogenesis of KATP channels

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7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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7 January 2021

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

1 reference

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7 January 2021

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

1 reference

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7 January 2021

Crystal structure of the potassium channel KirBac1.1 in the closed state

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.

1 reference

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7 January 2021

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

1 reference

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7 January 2021

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Functional characterization of a prokaryotic Kir channel

1 reference

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7 January 2021

Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate

1 reference

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7 January 2021

PIP2 and PIP as determinants for ATP inhibition of KATP channels

1 reference

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7 January 2021

Anionic phospholipids activate ATP-sensitive potassium channels

1 reference

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7 January 2021

Membrane phospholipid control of nucleotide sensitivity of KATP channels

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7 January 2021

SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions

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7 January 2021

Sur domains that associate with and gate KATP pores define a novel gatekeeper

1 reference

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7 January 2021

Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

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7 January 2021

Crystal structure of the ATP-binding subunit of an ABC transporter

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7 January 2021

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

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7 January 2021

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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7 January 2021

ATP binding properties of the nucleotide-binding folds of SUR1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Expression, purification, and evidence for the interaction of the two nucleotide-binding folds of the sulphonylurea receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Interactions of the sulfonylurea receptor 1 subunit in the molecular assembly of beta-cell K(ATP) channels

1 reference

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7 January 2021

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The open pore conformation of potassium channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Gating mechanism of KATP channels: function fits form

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Structural locus of the pH gate in the Kir1.1 inward rectifier channel.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Concerted gating mechanism underlying KATP channel inhibition by ATP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Flexibility of the Kir6.2 inward rectifier K(+) channel pore

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Modeling of an ion channel in its open conformation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Gating dependence of inner pore access in inward rectifier K(+) channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Nucleotides and phospholipids compete for binding to the C terminus of KATP channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Adenosine diphosphate as an intracellular regulator of insulin secretion.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Different Binding Properties and Affinities for ATP and ADP among Sulfonylurea Receptor Subtypes, SUR1, SUR2A, and SUR2B

1 reference

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7 January 2021

Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

ATPase activity of the sulfonylurea receptor: a catalytic function for the KATP channel complex.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Differential nucleotide regulation of KATP channels by SUR1 and SUR2A.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Tandem function of nucleotide binding domains confers competence to sulfonylurea receptor in gating ATP-sensitive K+ channels.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Gene targeting approach to clarification of ion channel function: studies of Kir6.x null mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Familial hyperinsulinism and pancreatic beta-cell ATP-sensitive potassium channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Genetic heterogeneity in familial hyperinsulinism.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Molecular determinants of KATP channel inhibition by ATP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

KCNJ11 activating mutations in Italian patients with permanent neonatal diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04711

7 January 2021

Identifiers

DOI

10.1038/NATURE04711

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

2621234

1023114032

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Fatcat ID

release_2j7bmmchpbb57dcgcmyokuxowa

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Fatcat

https://api.fatcat.wiki/v0/release/2j7bmmchpbb57dcgcmyokuxowa

24 November 2022

mapped directly with Wikidata item

2621234

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference