An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics (Q28298684)

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English	An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics	scientific article

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scholarly article

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An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics (English)

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transmembrane protein

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desensitization

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based on heuristic

inferred from title

author name string

S Weiland

1

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V Witzemann

2

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A Villarroel

3

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P Propping

4

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O Steinlein

5

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language of work or name

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publication date

25 November 1996

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398

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1

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91-6

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The diversity of neuronal nicotinic acetylcholine receptors

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https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

The alpha 5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

The permeation pathway of neurotransmitter-gated ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Refinement of the localization of the gene for neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) to human chromosome 20q13.2-q13.3

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Benign familial neonatal convulsions linked to genetic markers on chromosome 20.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Confirmation of linkage of benign familial neonatal convulsions to D20S19 and D20S20.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Localization of a gene for autosomal dominant nocturnal frontal lobe epilepsy to chromosome 20q 13.2

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Autosomal dominant frontal epilepsy misdiagnosed as sleep disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

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https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Role of acetylcholine receptor subunits in gating of the channel

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Genetic manipulation of ion channels: a new approach to structure and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Acetylcholine receptor channel imaged in the open state

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Nicotinic acetylcholine receptor at 9 A resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

A study of the desensitization produced by acetylcholine at the motor end-plate

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Desensitization at the frog neuromuscular junction: a biphasic process

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

21 January 2018

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2896%2901215-X

7 January 2021

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10.1016/S0014-5793(96)01215-X

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release_olc63qb7ijb2ndtft6jxdmlnv4

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