Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes (Q28291964)

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Y Ueki

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M Sugimoto

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Y Ninomiya

Journal of Biological Chemistry

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language of work or name

English

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publication date

10 November 1995

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published in

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volume

270

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issue

45

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page(s)

26863-7

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cites work

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Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors

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Colocalization of the genes for the alpha 3(IV) and alpha 4(IV) chains of type IV collagen to chromosome 2 bands q35-q37

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The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters

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DNA sequencing with chain-terminating inhibitors

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Dideoxy sequencing method using denatured plasmid templates

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Extensive structural differences between genes for the alpha 1 and alpha 2 chains of type IV collagen despite conservation of coding sequences.

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