From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research (Q28288721)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

review article

1 reference

title

From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

author name string

Bruce K Cassels

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Federico Dajas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

J Andrés Abin-Carriquiry

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Susan Wonnacott

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

language of work or name

English

0 references

publication date

1 December 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

issue

23-24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

1657-1665

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

Ca2+ permeability of nicotinic acetylcholine receptors

14 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Nicotinic acetylcholine receptors and the regulation of neuronal signalling.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Stimulation of nicotinic acetylcholine receptors protects motor neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Desensitization of neuronal nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Molecular and cellular aspects of nicotine abuse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Modulation of working, short- and long-term memory by nicotinic receptors in the basolateral amygdala in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Unconventional ligands and modulators of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Is Transduced into Cellular Responses in Neurons: Ca2+Signals and Neurotransmitter Release

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Effects of nicotinic stimulation on cognitive performance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Nicotinic acetylcholine involvement in cognitive function in animals

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Attentional effects of nicotinic agonists in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Smoking, nicotine and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Effects of nicotine on cognitive deficits in schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Effect of nicotine and nicotinic receptors on anxiety and depression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Transdermal nicotine and haloperidol in Tourette's disorder: a double-blind placebo-controlled study.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Mecamylamine moderates cue-induced emotional responses in smokers.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Transdermal nicotine for induction of remission in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Nicotine enemas for treatment of ulcerative colitis: a study of the pharmacokinetics and adverse events associated with three doses of nicotine.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Nicotinic receptors regulate B lymphocyte activation and immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and alpha4beta2 stably expressed in HEK293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Exploring the nature of molecular recognition in nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetize

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Epibatidine is a nicotinic analgesic

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Pharmacological effects of epibatidine optical enantiomers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

RECENT SYNTHESES OF EPIBATIDINE. A REVIEW

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Recent developments in the synthesis of nicotinic acetylcholine receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Loss of alpha-conotoxinMII- and A85380-sensitive nicotinic receptors in Parkinson's disease striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Epibatidine structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Some studies on cytisine and its methylated derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Synthesis of analogues of (-)-cytisine for in vivo studies of nicotinic receptors using positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Structure and activity of acetylcholine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Neuronal nicotinic acetylcholine receptor agonists: pharmacophores, evolutionary QSAR and 3D-QSAR models

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

A structural model of agonist binding to the α3β4 neuronal nicotinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Structure and gating mechanism of the acetylcholine receptor pore

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903665-2

7 January 2021

10.1016/S1359-6446(05)03665-2

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

775994

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16376826%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

775994

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

775994