The bacterial ribosome as a target for antibiotics (Q28279726)

Nature Reviews Microbiology

Europe PubMed Central

title

The bacterial ribosome as a target for antibiotics (English)

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2

Stephen Douthwaite

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author name string

Jacob Poehlsgaard

series ordinal

1

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language of work or name

English

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publication date

November 2005

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published in

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volume

3

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issue

11

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page(s)

870-81

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cites work

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

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Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics

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Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

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L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin

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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

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mRNA helicase activity of the ribosome

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The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

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Regulatory nascent peptides in the ribosomal tunnel

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Control of SecA and SecM translation by protein secretion

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

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Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.

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Structural origins of gentamicin antibiotic action

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Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

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Drugs targeting the ribosome

21 January 2018

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Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

21 January 2018

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The translation initiation functions of IF2: targets for thiostrepton inhibition.

21 January 2018

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Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain

21 January 2018

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Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria

21 January 2018

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A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

21 January 2018

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Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.

21 January 2018

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The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose

21 January 2018

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Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

21 January 2018

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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

21 January 2018

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Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

21 January 2018

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The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo

21 January 2018

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Recognition of the codon-anticodon helix by ribosomal RNA.

21 January 2018

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Insights into the decoding mechanism from recent ribosome structures

21 January 2018

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Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

21 January 2018

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An active role for tRNA in decoding beyond codon:anticodon pairing

21 January 2018

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Mutagenesis of 16S rRNA C1409-G1491 base-pair differentiates between 6'OH and 6'NH3+ aminoglycosides

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A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance

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Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea.

21 January 2018

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Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides

21 January 2018

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Instruction of translating ribosome by nascent peptide

21 January 2018

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Erythromycin resistance by ribosome modification

21 January 2018

1 reference

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The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome

21 January 2018

1 reference

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Insights into erythromycin action from studies of its activity as inducer of resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Short peptides conferring resistance to macrolide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Bacterial ribosomal subunit assembly is an antibiotic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Translation and protein synthesis: macrolides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Ketolides-telithromycin, an example of a new class of antibacterial agents

21 January 2018

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Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003.

21 January 2018

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Structural basis for the antibiotic activity of ketolides and azalides

21 January 2018

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23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

21 January 2018

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Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1265

Binding site of the bridged macrolides in the Escherichia coli ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Macrolide resistance conferred by base substitutions in 23S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1265

Properties of ribosomes from erythromycin resistant mutants of Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1265

Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

21 January 2018

1 reference

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Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage

21 January 2018

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In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

The macrolide binding site on the bacterial ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Peptide bond formation by in vitro selected ribozymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Parameters for crystal growth of ribosomal subunits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

Preliminary X-ray investigation of 70 S ribosome crystals from Thermus thermophilus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1265

31 March 2020

Identifiers

DOI

10.1038/NRMICRO1265

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1129140

1030281680

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Fatcat ID

release_6i7kjbnbrvexzlvtrzwtookeky

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Fatcat

https://api.fatcat.wiki/v0/release/6i7kjbnbrvexzlvtrzwtookeky

mapped directly with Wikidata item

24 November 2022

based on heuristic

1129140

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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