Graves' ophthalmopathy (Q28274196)

The New England Journal of Medicine

Europe PubMed Central

title

Graves' ophthalmopathy (English)

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author name string

Rebecca S Bahn

series ordinal

1

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language of work or name

English

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publication date

25 February 2010

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published in

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volume

362

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issue

8

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page(s)

726-38

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cites work

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29 September 2017

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29 September 2017

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29 September 2017

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Stimulation of adipogenesis, peroxisome proliferator-activated receptor-gamma (PPARgamma), and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts

29 September 2017

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29 September 2017

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Management of Graves' ophthalmopathy: reality and perspectives

29 September 2017

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Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy

29 September 2017

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The putative role of prostaglandin endoperoxide H synthase-2 in the pathogenesis of thyroid-associated orbitopathy

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy (TAO).

29 September 2017

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Retrobulbar pressures measured during surgical decompression of the orbit

29 September 2017

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Orbital tissue-derived T lymphocytes from patients with Graves' ophthalmopathy recognize autologous orbital antigens

29 September 2017

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The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota

29 September 2017

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Connective tissue, glycosaminoglycans, and diseases of the thyroid

29 September 2017

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Molecular cloning of the thyrotropin receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Thyrotropin interactions with human fat cell membrane preparations and the finding of a soluble thyrotropin binding component

29 September 2017

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Biological effects of thyrotropin receptor activation on human orbital preadipocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

The role of CD40 ligand in costimulation and T-cell activation

2 June 2018

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Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues

2 June 2018

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2 June 2018

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Temporal relationship between onset of Graves' ophthalmopathy and onset of thyroidal Graves' disease

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Clinical utility of thyrotropin-receptor antibody assays: comparison of radioreceptor and bioassay methods

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Rituximab treatment in a patient with severe thyroid-associated ophthalmopathy: effects on orbital lymphocytic infiltrates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Graves ophthalmopathy: the bony orbit in optic neuropathy, its apical angular capacity, and impact on prediction of risk.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

27 November 2018

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Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogs.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves' ophthalmopathy patients.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Reevaluating thyrotropin receptor-induced mouse models of graves' disease and ophthalmopathy.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

B cells, be gone--B-cell depletion in the treatment of rheumatoid arthritis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Thyroid associated ophthalmopathy: evidence for CD4(+) gammadelta T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of gammadelta and alphabeta T cell receptor expression

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Relative overexpression of macrophage-derived cytokines in orbital adipose tissue from patients with graves' ophthalmopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Long-term effects of Graves' ophthalmopathy on health-related quality of life

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Evidence for thyrotropin receptor immunoreactivity in pretibial connective tissue from patients with thyroid-associated dermopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3902010

Thyrotropin receptor expression in adrenal, kidney, and thymus

27 November 2018

1 reference

12 December 2020

Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopathy

1 reference

12 December 2020

Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor

1 reference

12 December 2020

Present concepts of the pathologic physiology of exophthalmos

1 reference

12 December 2020

Overexpression of immediate early genes in active Graves' ophthalmopathy

1 reference

12 December 2020

Infliximab: A Novel Treatment for Sight-Threatening Thyroid Associated Ophthalmopathy

1 reference

12 December 2020

The effect of etanercept on Graves' ophthalmopathy: a pilot study

1 reference

12 December 2020

Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.

1 reference

12 December 2020

Treatment-resistant severe, active Graves' ophthalmopathy successfully treated with B lymphocyte depletion

1 reference

12 December 2020

Thyrotropin receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the disease

1 reference

12 December 2020

Smoking and thyroid-associated ophthalmopathy: A novel explanation of the biological link

1 reference

12 December 2020

Treatment of Graves' disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study

1 reference

12 December 2020

Serum selenium levels in patients with remission and relapse of graves' disease

1 reference

12 December 2020

Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy

1 reference

12 December 2020

Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy

1 reference

12 December 2020

Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease

1 reference

12 December 2020

Graves' ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels: prevalence, natural history, and thyrotropin receptor antibody levels

1 reference

12 December 2020

Effect of tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta on adipogenesis and expression of thyrotropin receptor in human orbital preadipocyte fibroblasts

1 reference

12 December 2020

Development of anti-TNF therapy for rheumatoid arthritis

1 reference

12 December 2020

TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients

1 reference

12 December 2020

Robust induction of PGHS-2 by IL-1 in orbital fibroblasts results from low levels of IL-1 receptor antagonist expression

1 reference

12 December 2020

Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig

1 reference

12 December 2020

Dysthyroid ocular myopathy. Anatomy, histology, and electron microscopy

1 reference

12 December 2020

Appearance of Graves' disease on orbital computed tomography

1 reference

12 December 2020

Ophthalmopathy of Graves' disease: computerized volume measurements of the orbital fat and muscle

1 reference

12 December 2020

Clinical presentation of Graves' ophthalmopathy

1 reference

12 December 2020

Dysthyroid optic neuropathy without extraocular muscle involvement

1 reference

12 December 2020

Smoking and risk of Graves' disease

1 reference

12 December 2020

Thyrotropin receptor in non-thyroid tissues

1 reference

12 December 2020

Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue

1 reference

12 December 2020

Pathogenesis of Graves' ophthalmopathy

1 reference

12 December 2020

Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy

1 reference

12 December 2020

TSH receptor gene expression in retroocular fibroblasts

1 reference

12 December 2020

Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts

1 reference

12 December 2020

Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves' ophthalmopathy

1 reference

12 December 2020

Evidence of adipocyte differentiation in human orbital fibroblasts in primary culture

1 reference

12 December 2020

Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation

1 reference

12 December 2020

Thyrotropin receptor transcripts in human adipose tissue

1 reference

12 December 2020

Identifiers

DOI

10.1056/NEJMRA0905750

1 reference

931561

931561

1 reference

1 reference

1 reference