Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection (Q28270723)

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J G Cyster

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M L Hibbs

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A R Dunn

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K L Otipoby

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E A Clark

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C C Goodnow

Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.

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language of work or name

English

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publication date

April 1998

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published in

Immunity

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volume

8

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page(s)

497-508

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issue

4

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cites work

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A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

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Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

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Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases

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Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases

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Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C

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Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

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Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.

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Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

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The complexity of signaling pathways activated by the BCR.

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A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

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Genetic contributions to lupus-like disease in (NZB x NZW)F1 mice

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Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires

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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

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Induction of self-tolerance in mature peripheral B lymphocytes

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Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

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Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

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Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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Molecular mechanisms in B cell antigen receptor signaling

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Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

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CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation

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CD22 associates with the human surface IgM-B-cell antigen receptor complex

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Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice

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Polygenic control of susceptibility to murine systemic lupus erythematosus

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Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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CD22 is a negative regulator of B-cell receptor signalling

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Hyperresponsive B cells in CD22-deficient mice

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CD22 regulates thymus-independent responses and the lifespan of B cells.

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Association of CD22 with the B cell antigen receptor

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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition

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The basis of autoimmunity: Part II. Genetic predisposition

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Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

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7 January 2021

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22

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7 January 2021

Genetic analysis of autoimmune disease

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Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

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Evidence for a preformed transducer complex organized by the B cell antigen receptor

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Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

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