Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development (Q28267098)

2

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Warren S Pear

3

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Kathleen M Loomes

4

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Klaus H Kaestner

5

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Jonathan A Epstein

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

12 February 2008

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published in

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volume

105

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issue

6

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page(s)

1955-9

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2538864/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box

20 March 2017

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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

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The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

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Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

20 March 2017

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Essential role of endothelial Notch1 in angiogenesis

20 March 2017

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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

20 March 2017

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Dosage-sensitive requirement for mouse Dll4 in artery development

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Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway

20 March 2017

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

20 March 2017

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

20 March 2017

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Notch signalling: a simple pathway becomes complex

20 March 2017

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

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Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo

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Notch signaling is essential for vascular morphogenesis in mice

7 April 2017

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Developmental basis of vascular smooth muscle diversity

7 April 2017

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The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

29 September 2017

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An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

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Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

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Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.

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Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

29 September 2017

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Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway

29 September 2017

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Notch signaling is an important regulator of type 2 immunity.

29 September 2017

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Notch signaling represses myocardin-induced smooth muscle cell differentiation

29 September 2017

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

29 September 2017

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

29 September 2017

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Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors

29 September 2017

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Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality

29 September 2017

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Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

29 September 2017

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Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

29 September 2017

1 reference

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Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.

21 January 2018

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

21 January 2018

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

21 January 2018

1 reference

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Gene expression analysis by in situ hybridization. Radioactive probes

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18245384

12 December 2020

inferred from PubMed ID database lookup

Analysis of cardiovascular phenotype and genotype-phenotype correlation in individuals with a JAG1 mutation and/or Alagille syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18245384

12 December 2020

inferred from PubMed ID database lookup

Smooth Muscle alpha-actin is a direct target of Notch/CSL

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18245384

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0709663105

1 reference

4303723

ADS bibcode

2008PNAS..105.1955H

0 references

4303723

1 reference

1 reference

1 reference