Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies (Q28266067)

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English	Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies	scientific article

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scholarly article

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12 February 2020

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies (English)

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12 February 2020

phase I clinical trial

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Giuseppe Giaccone

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12 February 2020

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Len Neckers

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12 February 2020

William Douglas Figg, Sr.

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William D Figg

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Seth M Steinberg

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Seth M Steinberg

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Patricia S Steeg

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Shivaani Kummar

1

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12 February 2020

Martin E Gutierrez

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12 February 2020

Erin R Gardner

3

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Xiaohong Chen

4

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12 February 2020

Maria Zajac-Kaye

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12 February 2020

Min Chen

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12 February 2020

Christine A Muir

9

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12 February 2020

Mary Ann Yancey

10

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12 February 2020

Yvonne R Horneffer

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12 February 2020

Lamin Juwara

12

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12 February 2020

Giovanni Melillo

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12 February 2020

S Percy Ivy

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12 February 2020

Maria Merino

15

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12 February 2020

Barbara A Conley

18

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12 February 2020

James H Doroshow

20

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12 February 2020

Anthony J Murgo

21

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publication date

27 November 2009

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12 February 2020

European Journal of Cancer

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12 February 2020

46

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12 February 2020

340-347

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12 February 2020

2

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12 February 2020

Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones

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20 March 2017

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

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20 March 2017

Modulation of Akt kinase activity by binding to Hsp90

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20 March 2017

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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20 March 2017

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818572

20 March 2017

Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab

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29 September 2017

Heat shock protein 90 as a drug target: some like it hot.

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29 September 2017

Determination of 17-dimethylaminoethylamino-17-demethoxygeldanamycin in human plasma by liquid chromatography with mass-spectrometric detection

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818572

29 September 2017

Early tumor response to Hsp90 therapy using HER2 PET: comparison with 18F-FDG PET

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29 September 2017

Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

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29 September 2017

In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative

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29 September 2017

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

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29 September 2017

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

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29 September 2017

CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor.

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27 November 2018

Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance

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27 November 2018

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

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27 November 2018

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

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27 November 2018

Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts

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27 November 2018

Accelerated titration designs for phase I clinical trials in oncology

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19945858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19945858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJCA.2009.10.026

2 references

Consolidated OpenCitations Corpus – April 2017

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12 February 2020

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19945858%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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12 February 2020

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