Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs (Q28265606)

2

object named as

Shuohao Sun

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author name string

Vemuri B Reddy

1

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Ehsan Azimi

3

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Sarina B Elmariah

4

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Ethan A Lerner

describes a project that uses

6

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language of work or name

English

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publication date

28 July 2015

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published in

Nature Communications

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volume

6

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page(s)

7864

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4520244/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Endosomal generation of cAMP in GPCR signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Mechanisms of itch evoked by β-alanine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Cathepsin S elicits itch and signals via protease-activated receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Upregulation of cathepsin S in psoriatic keratinocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Cysteine cathepsin S as an immunomodulatory target: present and future trends.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Cysteine cathepsins: multifunctional enzymes in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Itch in psoriasis: epidemiology, clinical aspects and treatment options

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Plant cysteine proteases that evoke itch activate protease-activated receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

G protein-coupled receptors. I. Diversity of receptor-ligand interactions.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Pruritus in psoriasis. A prospective study of some psychiatric and dermatologic correlates.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520244

Behavioral differentiation between itch and pain in mouse

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8864

Overexpression of cathepsin S induces chronic atopic dermatitis in mice.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8864

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8864

Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation

21 January 2018

1 reference

12 December 2020

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis

1 reference

12 December 2020

The cleaved peptide of PAR1 results in a redistribution of the platelet surface GPIb-IX-V complex to the surface-connected canalicular system

1 reference

12 December 2020

Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS8864

1 reference

Dimensions Publication ID

4618385

ADS bibcode

2015NatCo...6.7864R

0 references

1051350487

0 references

4618385

1 reference

1 reference

1 reference