Emerging therapies for systemic lupus erythematosus--focus on targeting interferon-alpha (Q28265144)

ORCID Public Data File 2021

author name string

Eben I Lichtman

series ordinal

1

0 references

Simon M Helfgott

series ordinal

2

0 references

Martin A Kriegel

series ordinal

3

0 references

language of work or name

English

0 references

publication date

June 2012

0 references

published in

Clinical Immunology

0 references

volume

143

0 references

issue

3

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page(s)

210-21

0 references

cites work

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

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High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus

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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

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Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

20 March 2017

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

20 March 2017

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Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

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Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

20 March 2017

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A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese

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Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

20 March 2017

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

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Interferon alpha as a primary pathogenic factor in human lupus

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Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

29 September 2017

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Type I interferon and systemic lupus erythematosus

29 September 2017

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Interferon regulatory factors in human lupus pathogenesis

29 September 2017

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Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus

29 September 2017

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Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action

29 September 2017

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Association of a functional IRF7 variant with systemic lupus erythematosus

29 September 2017

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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

29 September 2017

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Current and novel therapeutics in the treatment of systemic lupus erythematosus

29 September 2017

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Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

29 September 2017

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29 September 2017

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Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus

29 September 2017

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29 September 2017

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Interferon alpha in systemic lupus erythematosus

29 September 2017

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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

29 September 2017

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African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity

29 September 2017

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Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.

29 September 2017

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Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

29 September 2017

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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

29 September 2017

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Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients

29 September 2017

1 reference

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Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

29 September 2017

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Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus

29 September 2017

1 reference

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Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study

29 September 2017

1 reference

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Cytoplasmic nucleic acid sensors in antiviral immunity

29 September 2017

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Recent insights into the genetic basis of systemic lupus erythematosus

29 September 2017

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Exposure to maternal smoking and incident SLE in a prospective cohort study

29 September 2017

1 reference

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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

29 September 2017

1 reference

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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Understanding the epidemiology and progression of systemic lupus erythematosus

29 September 2017

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Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Toll-like receptor and RIG-I-like receptor signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Development of TLR inhibitors for the treatment of autoimmune diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders

29 September 2017

1 reference

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Gene-environment interactions in the aetiology of systemic lupus erythematosus

29 September 2017

1 reference

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Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

29 September 2017

1 reference

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TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

29 September 2017

1 reference

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Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Ultraviolet light and cutaneous lupus

29 September 2017

1 reference

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The epigenetic face of systemic lupus erythematosus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

SLE--a disease of clearance deficiency?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Type I interferon dependence of plasmacytoid dendritic cell activation and migration.

29 September 2017

1 reference

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Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.

29 September 2017

1 reference

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Induction of clinical autoimmune disease by therapeutic interferon-alpha

29 September 2017

1 reference

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Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients

29 September 2017

1 reference

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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

29 September 2017

1 reference

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Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy

29 September 2017

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Serum alpha interferon and lymphocyte inclusions in systemic lupus erythematosus

29 September 2017

1 reference

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Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

29 September 2017

1 reference

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Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions

2 June 2018

1 reference

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Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus.

2 June 2018

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Immunological studies concerning the nephritis of systemic lupus erythematosus

2 June 2018

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An in vitro bioassay for quantitation of human interferons by measurements of antiproliferative activity on a continuous human lymphoma cell line

2 June 2018

1 reference

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Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Immune Interferon in the Circulation of Patients with Autoimmune Disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Systemic lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Type I interferonopathies: a novel set of inborn errors of immunity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

ELF1 is associated with systemic lupus erythematosus in Asian populations.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

The search for infectious causes of human cancers: where and why.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Association ofSTAT4andBLK, but notBANK1orIRF5, with primary antiphospholipid syndrome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Different genetic effects of interferon regulatory factor 5 (IRF5) polymorphisms on systemic lupus erythematosus in a Korean population.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Viruses and lupus: the viral hypothesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Systemic lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Mortality and causes of death in systemic lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

FCgammaRII (CD32)-dependent induction of interferon-alpha by serum from patients with lupus erythematosus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358492

Toll-like receptor signaling pathways

27 November 2018

1 reference

12 December 2020

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells

1 reference

12 December 2020

Epigenetics--the link between infectious diseases and cancer

1 reference

12 December 2020

Failure to detect antiviral activity in serum and plasma of healthy individuals displaying high activity in ELISA for IFN-alpha and IFN-beta

1 reference

12 December 2020

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

1 reference

12 December 2020

Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus

1 reference

12 December 2020

Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms

1 reference

12 December 2020