Potential therapeutic targets for neurokinin-1 receptor antagonists (Q28262693)

Expert Opinion on Emerging Drugs

Europe PubMed Central

title

Potential therapeutic targets for neurokinin-1 receptor antagonists (English)

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author name string

Ruth A Duffy

series ordinal

1

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language of work or name

English

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publication date

May 2004

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published in

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volume

9

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page(s)

9-21

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issue

1

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cites work

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NK1 receptor-mediated mechanisms regulate colonic hypersensitivity in the guinea pig.

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Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS.

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Effect of TAK-637, a tachykinin NK1-receptor antagonist, on lower urinary tract function in cats

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Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice

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Intraductal administration of an NK1 receptor antagonist attenuates the inflammatory response to retrograde infusion of radiological contrast in rats: implications for the pathogenesis and prevention of ERCP-induced pancreatitis.

21 January 2018

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The effect of substance P on peripheral blood mononuclear cells in patients with atopic dermatitis.

21 January 2018

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Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II.

21 January 2018

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Substance P enhances HIV-1 replication in latently infected human immune cells

21 January 2018

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Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium.

21 January 2018

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Substance P and Human Immunodeficiency Virus Infection: Psychoneuroimmunology

21 January 2018

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Elevated substance P levels in HIV-infected men.

21 January 2018

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Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes

21 January 2018

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A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes

21 January 2018

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Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis

21 January 2018

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Synthesis of peptide and pseudopeptide amides inhibiting the proliferation of small cell and epithelial types of lung carcinoma cells

21 January 2018

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[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy

21 January 2018

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Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum.

21 January 2018

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Rewarding effects of opiates are absent in mice lacking the receptor for substance P.

21 January 2018

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Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides

21 January 2018

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The role of spinal neuropeptides and prostaglandins in opioid physical dependence

21 January 2018

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Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons

21 January 2018

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Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists.

21 January 2018

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Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869.

21 January 2018

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Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of cisplatin-induced emesis

21 January 2018

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The substance P (NK1) receptor antagonist L-760735 inhibits fear conditioning in gerbils

21 January 2018

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Identification of the degradation product of ezlopitant, a non-peptidic substance P antagonist receptor, by hydrogen deuterium exchange, electrospray ionization tandem mass spectrometry (ESI/MS/MS) and nuclear magnetic resonance (NMR) spectroscopy

21 January 2018

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Substance P (Neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures.

21 January 2018

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Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

21 January 2018

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Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist

21 January 2018

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Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups

21 January 2018

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Validation of a chromatographic method to determine E-6006 and its metabolite E-6332 in rat and dog plasma by solid-phase extraction and capillary gas chromatography. Application in pharmacokinetics

21 January 2018

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SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical a

21 January 2018

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SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin 1 receptor: II. [...]

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https://api.crossref.org/works/10.1517%2F14728214.9.1.9

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Identifiers

DOI

10.1517/EOED.9.1.9.32956

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10.1517/14728214.9.1.9

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Consolidated OpenCitations Corpus – April 2017

1250969

1250969

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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