Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2 (Q28262686)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16030019%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2 (English)

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31 December 2019

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1

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31 December 2019

author name string

Terry P Lybrand

series ordinal

2

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31 December 2019

Richard M Breyer

series ordinal

3

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31 December 2019

language of work or name

English

0 references

publication date

19 July 2005

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Journal of Biological Chemistry

31 December 2019

published in

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31 December 2019

volume

280

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31 December 2019

page(s)

32442-32451

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31 December 2019

issue

37

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Release of prostaglandin D2 into human airways during acute antigen challenge

31 December 2019

cites work

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The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions

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Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine

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Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions

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Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1.

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Inflammatory cells in asthma: mechanisms and implications for therapy

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Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability

21 January 2018

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CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

21 January 2018

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Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis

21 January 2018

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

21 January 2018

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Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor

21 January 2018

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Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro

21 January 2018

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Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2

21 January 2018

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Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor

21 January 2018

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Three-Dimensional Models for β-Adrenergic Receptor Complexes with Agonists and Antagonists

21 January 2018

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Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach.

21 January 2018

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Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

21 January 2018

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

21 January 2018

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Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor

21 January 2018

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Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis

21 January 2018

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Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

21 January 2018

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Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype

21 January 2018

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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats

21 January 2018

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Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M502563200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16030019%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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