Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells (Q28260464)

Antony Galione

15

0 references

Lianne C Davis

Lianne C Davis

2

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Christian Grimm

Christian Grimm

7

0 references

Martin Biel

12

Martin Biel

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author name string

Margarida Ruas

1

0 references

Cheng-Chang Chen

3

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Anthony J Morgan

4

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Kai-Ting Chuang

5

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Timothy F Walseth

6

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Clive Garnham

8

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Trevor Powell

9

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Nick Platt

10

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Christian Wahl-Schott

13

0 references

John Parrington

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

14

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language of work or name

English

0 references

publication date

2 July 2015

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published in

The EMBO Journal

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volume

34

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page(s)

1743-58

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issue

13

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cites work

1 reference

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Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+

20 March 2017

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Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

20 March 2017

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20 March 2017

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mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

20 March 2017

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TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

20 March 2017

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Linking NAADP to ion channel activity: a unifying hypothesis

20 March 2017

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Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1

20 March 2017

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Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg

20 March 2017

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Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

20 March 2017

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Domain assembly of NAADP-gated two-pore channels

20 March 2017

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Two-pore channels form homo- and heterodimers

20 March 2017

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Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

20 March 2017

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An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

20 March 2017

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TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

20 March 2017

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Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

20 March 2017

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Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

20 March 2017

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NAADP mobilizes calcium from acidic organelles through two-pore channels

20 March 2017

1 reference

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NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

20 March 2017

1 reference

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Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients

20 March 2017

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Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

20 March 2017

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Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg

20 March 2017

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TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle

20 March 2017

1 reference

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The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores

20 March 2017

1 reference

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PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

20 March 2017

1 reference

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Calcium signalling: dynamics, homeostasis and remodelling

7 April 2017

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A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells

7 April 2017

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VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

29 September 2017

1 reference

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TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

29 September 2017

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Questioning regulation of two-pore channels by NAADP

29 September 2017

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Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes

29 September 2017

1 reference

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The voltage-gated sodium channel TPC1 confers endolysosomal excitability.

29 September 2017

1 reference

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Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants

29 September 2017

1 reference

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Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane.

29 September 2017

1 reference

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Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells

29 September 2017

1 reference

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How many Orai's does it take to make a CRAC channel?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

29 September 2017

1 reference

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Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells

29 September 2017

1 reference

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29 September 2017

1 reference

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Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes

29 September 2017

1 reference

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PIP2 is a necessary cofactor for ion channel function: how and why?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

The enigmatic TRPCs: multifunctional cation channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

The phosphoinositide PI(3,5)P₂ mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516428

Electrical measurements on endomembranes

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25872774

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201490009

1 reference

4502343

4502343

1 reference

1 reference

1 reference