Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly (Q28260017)

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23 January 2020

title

Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly (English)

1 reference

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23 January 2020

1 reference

4

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23 January 2020

James R Hagman

8

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23 January 2020

author name string

Laura A Lettice

1

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23 January 2020

Iain Williamson

2

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23 January 2020

John H Wiltshire

3

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23 January 2020

Paul S Devenney

5

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23 January 2020

Alison E Hill

6

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23 January 2020

Abdelkader Essafi

7

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23 January 2020

Richard Mort

9

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23 January 2020

Graeme Grimes

10

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23 January 2020

Carlo L DeAngelis

11

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23 January 2020

Robert E Hill

12

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23 January 2020

language of work or name

English

0 references

publication date

1 February 2012

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23 January 2020

number of pages

9

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based on heuristic

inferred from page(s)

published in

Developmental Cell

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23 January 2020

volume

22

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23 January 2020

issue

2

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23 January 2020

page(s)

459-467

1 reference

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EMAGE mouse embryo spatial gene expression database: 2010 update

23 January 2020

cites work

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A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

20 March 2017

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Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

20 March 2017

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20 March 2017

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Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

20 March 2017

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Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers

24 May 2017

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Preaxial polydactyly/triphalangeal thumb is associated with changed transcription factor-binding affinity in a family with a novel point mutation in the long-range cis-regulatory element ZRS

29 September 2017

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DNA specificity determinants associate with distinct transcription factor functions

29 September 2017

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Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb

29 September 2017

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29 September 2017

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A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb

29 September 2017

1 reference

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How to make a zone of polarizing activity: insights into limb development via the abnormality preaxial polydactyly

29 September 2017

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Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

29 September 2017

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Making digit patterns in the vertebrate limb

29 September 2017

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The ETS transcription factor GABPalpha is essential for early embryogenesis

29 September 2017

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Homotypic regulatory clusters in Drosophila.

29 September 2017

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Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site.

29 September 2017

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Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo

29 September 2017

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Human ETS1 oncoprotein. Purification, isoforms, -SH modification, and DNA sequence-specific binding

29 September 2017

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Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells

29 September 2017

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A specific mutation in the distant sonic hedgehog (SHH) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb

2 June 2018

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Homozygous feature of isolated triphalangeal thumb-preaxial polydactyly linked to 7q36: no phenotypic difference between homozygotes and heterozygotes

27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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Two novel point mutations in the long-range SHH enhancer in three families with triphalangeal thumb and preaxial polydactyly

27 November 2018

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Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.

27 November 2018

1 reference

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27 November 2018

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27 November 2018

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22340503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The ETS-domain transcription factor family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22340503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DEVCEL.2011.12.010

2 references

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23 January 2020

1 reference

2 references

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23 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22340503%20AND%20SRC:MED&resulttype=core&format=json