Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival (Q28251982)

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English	Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival	scientific article

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scholarly article

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27 December 2019

Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival (English)

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27 December 2019

apoptotic process

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phosphorylation

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Fyn proto-oncogene

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GOA release 2020-03-11

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

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GOA release 2020-03-11

2

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27 December 2019

author name string

Tang X

1

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27 December 2019

Ye K

3

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27 December 2019

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publication date

14 July 2006

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27 December 2019

Cell Death & Differentiation

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27 December 2019

14

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27 December 2019

2

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27 December 2019

368-377

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27 December 2019

TCR signals mediated by Src family kinases are essential for the survival of naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

21 January 2018

Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

New roles for Src kinases in control of cell survival and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Association between the PDGF receptor and members of the src family of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Initial events of myelination involve Fyn tyrosine kinase signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

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Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

inferred from DOI database lookup

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402011

7 January 2021

based on heuristic

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Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor

1 reference

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7 January 2021

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Identifiers

10.1038/SJ.CDD.4402011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16841086%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

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27 December 2019

ResearchGate publication ID

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Springer Nature article ID

10.1038/sj.cdd.4402011

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