Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver (Q28246572)

1

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Suzanne de la Monte

2

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Masayoshi Horimoto

4

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Arlin B Rogers

5

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Betty L Slagle

6

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Jack R Wands

Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells

7

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language of work or name

English

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publication date

June 2009

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published in

Hepatology

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volume

49

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issue

6

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page(s)

1935-43

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cites work

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Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness

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Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) β-hydroxylase suppress migration of cholangiocarcinoma cells

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Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

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Cloning and increased expression of an insulin receptor substrate - 1-like gene in human hepatocellular carcinoma

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Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only

20 March 2017

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Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

29 September 2017

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Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis

29 September 2017

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Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma

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HBV induced carcinogenesis

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Effects of hepatitis B virus X protein on the development of liver cancer

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Wnt/Frizzled signaling in hepatocellular carcinoma

29 September 2017

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Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma

29 September 2017

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Wnt signaling in disease and in development

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An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis

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PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

29 September 2017

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Molecular viral oncology of hepatocellular carcinoma

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Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions

29 September 2017

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Genetics of hepatocellular carcinoma

29 September 2017

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Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice

29 September 2017

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

29 September 2017

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Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras

29 September 2017

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A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype

29 September 2017

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Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules

29 September 2017

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Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

29 September 2017

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Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

29 September 2017

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Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

29 September 2017

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Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

29 September 2017

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Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene

2 June 2018

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

2 June 2018

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Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

2 June 2018

1 reference

Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes.

21 January 2018

1 reference

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma.

21 January 2018

1 reference

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

21 January 2018

1 reference

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

21 January 2018

1 reference

Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.

21 January 2018

1 reference

Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms.

21 January 2018

1 reference

Increased expression of insulin-like growth factor 2 in hepatocellular carcinoma is primarily regulated at the transcriptional level

21 January 2018

1 reference

12 December 2020

Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma

1 reference

12 December 2020

Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression

1 reference

12 December 2020

Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor

1 reference

12 December 2020