Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site (Q28243447)

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10 January 2020

title

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site (English)

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10 January 2020

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2

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10 January 2020

author name string

Siraj M Ali

series ordinal

1

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language of work or name

English

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publication date

4 April 2005

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Journal of Biological Chemistry

10 January 2020

published in

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volume

280

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10 January 2020

page(s)

19445-19448

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issue

20

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

10 January 2020

cites work

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https://api.crossref.org/works/10.1074%2FJBC.C500125200

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C500125200

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Structural and functional analysis of pp70S6k

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C500125200

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C500125200

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells

21 January 2018

1 reference

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Lentivirus-delivered stable gene silencing by RNAi in primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C500125200

21 January 2018

Identifiers

DOI

10.1074/JBC.C500125200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15809305%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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