Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway (Q28241789)

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object named as

Barry V L Potter

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author name string

Enza Piccolo

1

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Sara Vignati

2

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Tania Maffucci

3

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Pasquale F Innominato

4

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Andrew M Riley

5

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Massimo Broggini

8

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Stefano Iacobelli

9

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Paolo Innocenti

10

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Marco Falasca

Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate

11

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language of work or name

English

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publication date

4 March 2004

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published in

Oncogene

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volume

23

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issue

9

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page(s)

1754-65

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cites work

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Phosphoinositide kinases

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol

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The role of phosphoinositide 3-kinase lipid products in cell function

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Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR.

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Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.

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Transport of the highly charged myo-inositol hexakisphosphate molecule across the red blood cell membrane: a phase transfer and biological study

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Mechanism of activation of protein kinase B by insulin and IGF-1

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7 January 2021

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

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Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

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Patterns within protein/polyphosphoinositide interactions provide specific targets for therapeutic intervention

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Regulation of cell death protease caspase-9 by phosphorylation

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

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Pten is essential for embryonic development and tumour suppression

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Mechanisms and consequences of activation of protein kinase B/Akt

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

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PI3K: downstream AKTion blocks apoptosis

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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Mechanisms of cancer drug resistance

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Pleckstrin domain homology

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Induction of NF-kappaB by the Akt/PKB kinase

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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Pleckstrin homology domains.

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

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Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

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Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

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7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines

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Extracellular matrix regulation of drug resistance in small-cell lung cancer

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

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7 January 2021

The pleckstrin homology domain: an intriguing multifunctional protein module

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7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

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7 January 2021

Assessing the omnipotence of inositol hexakisphosphate

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7 January 2021

Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

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7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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7 January 2021

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

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7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

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7 January 2021

Phosphoinositide 3-kinases: a conserved family of signal transducers

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7 January 2021

p27Kip1 overexpression causes apoptotic death of mammalian cells

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7 January 2021