Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car (Q28239141)

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

Europe PubMed Central

title

Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car (English)

0 references

author name string

Susumu Kodama

series ordinal

1

0 references

Masahiko Negishi

series ordinal

2

0 references

language of work or name

English

0 references

publication date

2006

0 references

published in

Drug Metabolism Reviews

0 references

volume

38

0 references

page(s)

75-87

0 references

issue

1-2

0 references

cites work

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600569851

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

FoxO proteins in insulin action and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Treatment of itching associated with intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

CAR, driving into the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569851