Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase (Q28215911)

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scientific article (publication date: 5 April 2002)

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English	Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase	scientific article (publication date: 5 April 2002)

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scholarly article

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Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase (English)

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phosphorylation

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based on heuristic

inferred from title

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author name string

Hiroki Chikumi

1

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Shigetomo Fukuhara

2

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J Silvio Gutkind

3

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language of work or name

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publication date

5 April 2002

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Journal of Biological Chemistry

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277

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12463-73

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14

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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Proteins regulating Ras and its relatives

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Rho GTPases and signaling networks

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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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Bioactive lysophospholipids and their G protein-coupled receptors

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G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

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The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

1 reference

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Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

1 reference

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p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

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Structure of the RGS-like Domain from PDZ-RhoGEF

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RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

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The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

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Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction

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G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.

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Thrombin signalling and protease-activated receptors

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Platelet tyrosine-specific protein phosphorylation is regulated by thrombin

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Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets

1 reference

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G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

1 reference

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

1 reference

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Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation

1 reference

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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

1 reference

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Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway

1 reference

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Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

1 reference

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Tyrosine kinase inhibition: an approach to drug development

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Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

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Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor.G protein coupling

1 reference

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G proteins: transducers of receptor-generated signals

1 reference

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

1 reference

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Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate

1 reference

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Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate

1 reference

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Microinjection of recombinant p21rho induces rapid changes in cell morphology

1 reference

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A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

1 reference

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p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking

1 reference

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An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

1 reference

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

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Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

1 reference

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1 reference

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Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation

1 reference

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

1 reference

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Autoinhibition mechanism of proto-Dbl.

1 reference

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Structure of the rgRGS domain of p115RhoGEF

1 reference

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Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

1 reference

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21 January 2018

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